General Thoracic and Cardiovascular Surgery

, Volume 61, Issue 8, pp 455–459 | Cite as

Clinical benefits of methylprednisolone in off-pump coronary artery bypass surgery

  • Takanori SuezawaEmail author
  • Atsushi Aoki
  • Mitsuhisa Kotani
  • Mamoru Tago
  • Osamu Kobayashi
  • Akihito Hirasaki
  • Minako Sano
  • Nana Kameda
  • Hiroki Mitsunaka
Original Article



It has not been established whether off-pump coronary artery bypass grafting (OPCABG) is less invasive than conventional CABG. In our experience, OPCABG has several advantages such as shorter operative duration, decreased requirement of blood transfusion and myocardial protection compared with conventional CABG. However, frequency of postoperative paroxysmal atrial fibrillation (PAF) is similar between these techniques and early postoperative C-reactive protein (CRP) levels have been shown to be significantly higher in OPCABG. We hypothesized that preoperative steroid administration, routinely used only in conventional CABG, may alleviate high postoperative PAF and CRP levels. Therefore, a prospective, double-blind, clinical trial was conducted in OPCABG patients to investigate the clinical effects of preoperative steroid administration.


Thirty OPCABG patients were randomly divided into 2 groups: control (Group C: n = 15) and methylprednisolone (Group M: n = 15) groups. Group M patients were intravenously administered 1000 mg methylprednisolone during anesthesia induction.


Hospital death and infectious complication such as mediastinitis were not observed in either group. Postoperative PAF occurred in 47 % (7/15) of patients in group C but in only 1 patient in group M (7 %, P = 0.013). Early postoperative CRP levels were significantly lower in group M than in group C (peak values on postoperative day 2: group M 15 ± 6 mg/dL vs. group C 23 ± 4 mg/dL; P = 0.0002).


Preoperative steroid administration in OPCABG patients significantly suppresses CRP elevation and prevents postoperative PAF without increasing in-hospital mortality or infectious complications.


Off-pump coronary artery bypass Methylprednisolone Atrial fibrillation Inflammation 



The authors thank Drs. Rikiya Matsuda, Akihiro Nagai, Sawako Takebe, Yuichi Yatsu, Kazuyoshi Inoue, Masaharu Nagae and Shinkichi Otani for collection of data.


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Copyright information

© The Japanese Association for Thoracic Surgery 2013

Authors and Affiliations

  • Takanori Suezawa
    • 1
    Email author
  • Atsushi Aoki
    • 1
  • Mitsuhisa Kotani
    • 1
  • Mamoru Tago
    • 1
  • Osamu Kobayashi
    • 2
  • Akihito Hirasaki
    • 2
  • Minako Sano
    • 2
  • Nana Kameda
    • 2
  • Hiroki Mitsunaka
    • 3
  1. 1.Department of Cardiovascular SurgeryKagawa Prefectural Central HospitalTakamatsuJapan
  2. 2.Department of AnesthesiologyKagawa Prefectural Central HospitalTakamatsuJapan
  3. 3.Department of RheumatologyKagawa Prefectural Central HospitalTakamatsuJapan

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