Skip to main content
Log in

Surgical treatment for acute type A aortic dissection during pregnancy (16 weeks) with Loeys-Dietz syndrome

  • Case Report
  • Published:
General Thoracic and Cardiovascular Surgery Aims and scope Submit manuscript

Abstract

A 32-year-old woman at 16 weeks of pregnancy was diagnosed with acute type A aortic dissection and severe aortic regurgitation. Aortic valve and aortic arch replacement was successfully performed under circulatory arrest with deep hypothermia. After the operation, she was diagnosed with Loeys-Dietz syndrome. At 36 weeks of gestation, the patient underwent a cesarean section and delivered a healthy baby.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1

Similar content being viewed by others

References

  1. Immer FF, Bansi AG, Immer-Bansi AS, McDougall J, Zehr KJ, Schaff HV, et al. Aortic dissection in pregnancy: analysis of risk factors and outcome. Ann Thorac Surg. 2003;76:309–14.

    Article  PubMed  Google Scholar 

  2. Meijboom LJ, Vos FE, Timmermans J, Boers GH, Zwinderman AH, Mulder BJ. Pregnancy and aortic root growth in the Marfan syndrome: a prospective study. Eur Heart J. 2005;26:914–20.

    Article  PubMed  Google Scholar 

  3. Pomini F, Mercogliano D, Cavalletti C, Caruso A, Pomini P. Cardiopulmonary bypass in pregnancy. Ann Thorac Surg. 1996;61:259–68.

    Article  PubMed  CAS  Google Scholar 

  4. Sakaguchi M, Kitahara H, Seto T, Furusawa T, Fukui D, Yanagiya N, et al. Surgery for acute type A aortic dissection in pregnancy patients with Marfan syndrome. Eur J Cardiothorac Surg. 2005;28:280–5.

    Article  PubMed  Google Scholar 

  5. Weiss BM, von Segesser LK, Alon E, Seifert B, Turina MI. Outcome of cardiovascular surgery and pregnancy: a systematic review of the period 1984–1996. Am J Obstet Gynecol. 1998;179:1643–53.

    Article  PubMed  CAS  Google Scholar 

  6. Rossiter JP, Repke JT, Morales AJ, Murphy EA, Pyeritz RE. A prospective longitudinal evaluation of pregnancy in the Marfan syndrome. Am J Obstet Gynecol. 1995;173:1599–606.

    Article  PubMed  CAS  Google Scholar 

  7. Spittell PC, Spittell JA Jr, Joyce JW, Tajik AJ, Edwards WD, Schaff HV, et al. Clinical features and differential diagnosis of aortic dissection: experience with 236 cases (1980 through 1990). Mayo Clin Proc. 1993;68:642–51.

    PubMed  CAS  Google Scholar 

  8. Barrett JM, Van Hooydonk JE, Boehm FH. Pregnancy related rupture of arterial aneurysms. Obstetr Gynecol Survey. 1982;37:557–66.

    Article  CAS  Google Scholar 

  9. Buffolo E, Palma JH, Gomes WJ, Vega H, Born D, Moron AF, et al. Successful use of deep hypothermic circulatory arrest in pregnancy. Ann Thorac Surg. 1994;58:1532–4.

    Article  PubMed  CAS  Google Scholar 

  10. Cremer J, Martin M, Redl H, Bahrami S, Abraham C, Graeter T, et al. Systemic inflammatory response syndrome after cardiac operations. Ann Thorac Surg. 1996;61:1714–20.

    Article  PubMed  CAS  Google Scholar 

  11. Becker RM. Intracardiac surgery in pregnant women. Ann Thorac Surg. 1983;36:453–8.

    Article  PubMed  CAS  Google Scholar 

  12. Mul TF, van Herwerden LA, Chen-Overbeck TE, Catsman-Berrevoets CE, Lotgering FK. Hypoxic-ischemic fetal insult resulting from maternal aortic root replacement, with normal fatal heart rate at term. Am J Obstet Gynecol. 1998;179:825–7.

    Article  PubMed  CAS  Google Scholar 

  13. Oran B, Lee-Parritz A, Ansell J. Low molecular weight heparin for the prophylaxis of thromboembolism in women with prosthetic mechanical heart valves during pregnancy. Thromb Haemost. 2004;92:747–51.

    PubMed  CAS  Google Scholar 

  14. Loeys BL, Chen J, Nepture ER, Judge DP, Podowski M, Holm T, et al. A syndrome of altered cardiovascular, craniofacial, neurocognitive and skeletal development caused by mutations in TGFBR1 or TGFBR2. Nat Genet. 2005;37:275–81.

    Article  PubMed  CAS  Google Scholar 

  15. Loeys BL, Schwarze U, Holm T, Callewaert BL, Thomas GH, Pannu H, et al. Aneurysm syndromes caused by mutations in the TGF-beta receptor. N Engl J Med. 2006;355:788–98.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Hideyuki Kunishige.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Kunishige, H., Ishibashi, Y., Kawasaki, M. et al. Surgical treatment for acute type A aortic dissection during pregnancy (16 weeks) with Loeys-Dietz syndrome. Gen Thorac Cardiovasc Surg 60, 764–767 (2012). https://doi.org/10.1007/s11748-012-0073-8

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11748-012-0073-8

Keywords

Navigation