General Thoracic and Cardiovascular Surgery

, Volume 59, Issue 2, pp 91–97 | Cite as

Tissue-engineered airway and “in situ tissue engineering”

  • Tatsuo Nakamura
  • Koichi Ohmori
  • Shin-ichi Kanemaru
Current Topics Review Article


Since the 1980s, tissue engineering has become one of the major areas of endeavor in medical research, applying the principles of biology and engineering to the development of functional substitutes for damaged tissue. Using this technology, various attempts have been made to create and apply a tissue-engineered prosthetic trachea, or airway. In addition to the conventional tissue engineering approach, a new substantially different concept has been advocated in Japan since 2000. This is “in situ tissue engineering,” where a tissue is created not in vitro but in vivo, exploiting the potential of the living body for wound healing. An artificial trachea created by in situ tissue engineering has already been applied in human patients for reconstruction of airway defects, and promising results have been obtained. This article reviews recent progress in the relatively new field of airway reconstruction employing tissue engineering.

Key words

Artificial trachea In situ tissue engineering Tracheal prosthesis Adipose-derived stromal cell (ASC) Induced pluripotent stem (iPS) cells 


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Copyright information

© The Japanese Association for Thoracic Surgery 2011

Authors and Affiliations

  • Tatsuo Nakamura
    • 1
  • Koichi Ohmori
    • 2
  • Shin-ichi Kanemaru
    • 3
  1. 1.Institute for Frontier Medical SciencesKyoto UniversityKyotoJapan
  2. 2.Department of OtorhinolaryngologyFukushima Medical UniversityFukushimaJapan
  3. 3.Department of OtolaryngologyHead & Neck Surgery, Kitano HospitalOsakaJapan

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