Lipids

, Volume 50, Issue 4, pp 339–347 | Cite as

Postprandial Lipid Responses do not Differ Following Consumption of Butter or Vegetable Oil when Consumed with Omega-3 Polyunsaturated Fatty Acids

  • Cintia B. Dias
  • Melinda Phang
  • Lisa G. Wood
  • Manohar L. Garg
Original Article

Abstract

Dietary saturated fat (SFA) intake has been associated with elevated blood lipid levels and increased risk for the development of chronic diseases. However, some animal studies have demonstrated that dietary SFA may not raise blood lipid levels when the diet is sufficient in omega-3 polyunsaturated fatty acids (n-3PUFA). Therefore, in a randomised cross-over design, we investigated the postprandial effects of feeding meals rich in either SFA (butter) or vegetable oil rich in omega-6 polyunsaturated fatty acids (n-6PUFA), in conjunction with n-3PUFA, on blood lipid profiles [total cholesterol, low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C) and triacylglycerol (TAG)] and n-3PUFA incorporation into plasma lipids over a 6-h period. The incremental area under the curve for plasma cholesterol, LDL-C, HDL-C, TAG and n-3PUFA levels over 6 h was similar in the n-6PUFA compared to SFA group. The postprandial lipemic response to saturated fat is comparable to that of n-6PUFA when consumed with n-3PUFA; however, sex-differences in response to dietary fat type are worthy of further attention.

Keywords

Postprandial lipemia Saturated fat n-6PUFA n-3PUFA Plasma lipids 

Abbreviations

CVD

Cardiovascular disease

DHA

Docosahexaenoic acid

EDTA

Ethylenediaminetetraacetic acid

EPA

Eicosapentaenoic acid

HDL-C

High density lipoprotein cholesterol

iAUC

Incremental area under the curve

LCn-3PUFA

Long chain omega-3 polyunsaturated fatty acids

LDL-C

Low density lipoprotein cholesterol

PUFA

Polyunsaturated fatty acids

n-3PUFA

Omega-3 polyunsaturated fatty acids

n-6PUFA

Omega-3 polyunsaturated fatty acids

SFA

Saturated fat

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Copyright information

© AOCS 2015

Authors and Affiliations

  • Cintia B. Dias
    • 1
  • Melinda Phang
    • 1
  • Lisa G. Wood
    • 2
  • Manohar L. Garg
    • 1
  1. 1.Nutraceuticals Research Group, School of Biomedical Sciences and PharmacyUniversity of NewcastleCallaghanAustralia
  2. 2.Centre for Asthma and Respiratory Disease, School of Biomedical Sciences and PharmacyUniversity of NewcastleCallaghanAustralia

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