, Volume 48, Issue 12, pp 1197–1205 | Cite as

The Effect of an Energy Restricted Low Glycemic Index Diet on Blood Lipids, Apolipoproteins and Lipoprotein (a) Among Adolescent Girls with Excess Weight: a Randomized Clinical Trial

  • Mohammad Hossein Rouhani
  • Roya Kelishadi
  • Mahin Hashemipour
  • Ahmad Esmaillzadeh
  • Leila AzadbakhtEmail author
Original Article


Some studies focused on the effect of the dietary glycemic index on lipoproteins and apolipoproteins in adults; however, little evidence exists among adolescents regarding the effect of a low glycemic index (LGI) diet on apolipoproteins and lipoprotein (a) (Lpa). This study was conducted to evaluate the effect of an LGI diet on the lipid profile, apolipoproteins and Lpa among overweight and obese adolescent girls. For this parallel designed randomized clinical trial, 50 healthy overweight/obese girls at pubertal ages were randomly allocated to an LGI or a healthy nutritional recommendations (HNR) based diet. Equal macronutrient distributed diets were prescribed to both groups. Biochemical measurements included lipid profile, apolipoprotein A, apolipoprotein B and Lpa were conducted before and after 10 weeks of intervention. Forty one adolescent girls completed the study. The dietary glycemic index in the LGI group was 42.67 ± 0.067. There were no differences in the mean of blood lipid indices baseline and after intervention between two groups. There were no significant differences between the two groups regarding lipid profiles, apolipoproteins and Lpa. There were no significant differences in lipid profiles, apolipoproteins and Lpa between the LGI diet and the HNR-based diet and the impact of these two diets on lipid profile was equal in this trial. Trial registry code: IRCT201109272839N4.


Carbohydrate quality Hyperlipidemia Obesity 



Glycemic index


High density lipoprotein(s)


High glycemic index


Healthy nutritional recommendations


Low density lipoprotein(s)


Low glycemic index


Lipoprotein (a)





The Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran has supported this study with a grant for which we are grateful.

Conflict of interest

The authors have no conflicts of interests.


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Copyright information

© AOCS 2013

Authors and Affiliations

  • Mohammad Hossein Rouhani
    • 1
  • Roya Kelishadi
    • 2
  • Mahin Hashemipour
    • 2
    • 3
  • Ahmad Esmaillzadeh
    • 1
  • Leila Azadbakht
    • 1
    Email author
  1. 1.Food Security Research Center and Department of Community Nutrition, School of Nutrition and Food ScienceIsfahan University of Medical SciencesIsfahanIran
  2. 2.Department of Pediatrics, Child Growth and Development Research Center, and School of MedicineIsfahan University of Medical SciencesIsfahanIran
  3. 3.Department of Pediatric Endocrinology and Metabolism Diseases, Endocrinology and Metabolism Research Center, School of MedicineIsfahan University of Medical SciencesIsfahanIran

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