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Lipids

, Volume 47, Issue 6, pp 643–646 | Cite as

Oral Supplementation with Dihomo-γ-Linolenic Acid (DGLA)-Enriched Oil Increases Serum DGLA Content in Healthy Adults

  • Takao Tanaka
  • Saki Kakutani
  • Chika Horikawa
  • Hiroshi KawashimaEmail author
  • Yoshinobu Kiso
Communication

Abstract

Dihomo-γ-linolenic acid (DGLA) is one of the polyunsaturated fatty acids, and is expected to show anti-allergic activity. We examined the effects of supplementation with DGLA-enriched oil (450 mg as free DGLA) for 4 weeks in healthy adults in a randomized controlled study. The DGLA composition in the total fatty acids of serum phospholipids increased from 2.0 to 3.4 %, and returned to the initial level after a 4-week washout. No side effects or changes in blood biochemical parameters were observed. These results indicate that serum DGLA content can be safely increased by supplementation with 450 mg DGLA under these conditions.

Keywords

Polyunsaturated fatty acid Dihomo-γ-linolenic acid DGLA Atopic dermatitis Human 

Abbreviations

AD

Atopic dermatitis

ARA

Arachidonic acid

DGLA

Dihomo-γ-linolenic acid

DGLA oil

DGLA-enriched triglyceride

DHA

Docosahexaenoic acid

GLA

γ-Linolenic acid

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Copyright information

© AOCS 2012

Authors and Affiliations

  • Takao Tanaka
    • 1
  • Saki Kakutani
    • 1
  • Chika Horikawa
    • 1
  • Hiroshi Kawashima
    • 1
    Email author
  • Yoshinobu Kiso
    • 1
  1. 1.Institute for Health Care Science, Suntory Wellness Ltd.ShimamotoJapan

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