Lipids

, Volume 46, Issue 11, pp 1071–1074 | Cite as

A Perinatal Palatable High-Fat Diet Increases Food Intake and Promotes Hypercholesterolemia in Adult Rats

  • Tchana Weyll Souza Oliveira
  • Carol Góis Leandro
  • Tereza Cristina Bomfim de Jesus Deiró
  • Gabriela dos Santos Perez
  • Darlene da França Silva
  • Janice Izabel Druzian
  • Ricardo David Couto
  • Jairza Maria Barreto-Medeiros
Communication

Abstract

The main goal of the present study was to evaluate the long-term effects of a perinatal palatable high-fat diet on the food intake and cholesterol profile of adult rats. Male Wistar rats (aged 22 days) were divided into two groups according to their mother’s diet during gestation and lactation (C p, n = 10; pups from control mothers; and HLp n = 10; pups from mothers fed a palatable high-fat diet). At the 76th day, pups were housed individually for 14 days, and daily food consumption was determined during a period of 6 days. Blood from 100-day-old rats was sampled by cardiac puncture. Fasting (12 h) serum glucose, total cholesterol, LDL-C, HDL-C, triglycerides (TG), and VLDL-C levels were determined. The measurement of food intake was higher in the animals submitted to a hyperlipidic diet during the perinatal period. Serum total cholesterol, LDL-C, HDL-C, TG, VLDL-C and glycemia were increased in the HLp group compared to the control group. Our findings show that an early life environment with a high-fat diet can contribute to metabolic disease in later life.

Keywords

Hyperlipidic diet Cholesterolemia Rats Developmental plasticity Critical period of development 

Abbreviations

Cp

Control pups

HLp

Hyperlipid diet pups

HDL-C

High-density-lipoprotein cholesterol

LDL-C

Low-density-lipoprotein cholesterol

MUFA

Monounsaturated fatty acids

ND

Not detected

PUFA

Polyunsaturated fatty acids

SFA

Saturated fatty acids

TFA

Trans fatty acids

VLDL-C

Very-low-density-lipoprotein cholesterol

Notes

Acknowledgments

This study received financial support from the CNPq and FAPESB.

References

  1. 1.
    Barker DJ (2007) The origins of the developmental origins theory. J Intern Med 261:412–417PubMedCrossRefGoogle Scholar
  2. 2.
    Gluckman PD, Hanson MA, Spencer HG, Bateson P (2005) Environmental influences during development and their later consequences for health and disease: implications for the interpretation of empirical studies. Proc Biol Sci 272:671–677PubMedCrossRefGoogle Scholar
  3. 3.
    Ozanne SE, Hales CN (2004) Lifespan: catch-up growth and obesity in male mice. Nature 427:411–412PubMedCrossRefGoogle Scholar
  4. 4.
    Gluckman PD, Hanson MA (2007) Developmental plasticity and human disease: research directions. J Intern Med 261:461–471PubMedCrossRefGoogle Scholar
  5. 5.
    Barreto-Medeiros JM, Feitoza EG, Magalhaes K, Cabral-Filho JE, Manhaes-De-Castro FM, De-Castro CM, Manhaes-De-Castro R (2004) Malnutrition during brain growth spurt alters the effect of fluoxetine on aggressive behavior in adult rats. Nutr Neurosci 7:49–52PubMedCrossRefGoogle Scholar
  6. 6.
    Orozco-Solis R, Lopes de Souza S, Barbosa Matos RJ, Grit I, Le Bloch J, Nguyen P, Manhaes de Castro R, Bolanos-Jimenez F (2009) Perinatal undernutrition-induced obesity is independent of the developmental programming of feeding. Physiol Behav 96:481–492PubMedCrossRefGoogle Scholar
  7. 7.
    Toscano AE, Manhaes-de-Castro R, Canon F (2008) Effect of a low-protein diet during pregnancy on skeletal muscle mechanical properties of offspring rats. Nutrition 24:270–278PubMedCrossRefGoogle Scholar
  8. 8.
    Shankar K, Harrell A, Liu X, Gilchrist JM, Ronis MJ, Badger TM (2008) Maternal obesity at conception programs obesity in the offspring. Am J Physiol Regul Integr Comp Physiol 294:R528–R538PubMedCrossRefGoogle Scholar
  9. 9.
    Buckley AJ, Keseru B, Briody J, Thompson M, Ozanne SE, Thompson CH (2005) Altered body composition and metabolism in the male offspring of high fat-fed rats. Metabolism 54:500–507PubMedCrossRefGoogle Scholar
  10. 10.
    Chechi K, Cheema SK (2006) Maternal diet rich in saturated fats has deleterious effects on plasma lipids of mice. Exp Clin Cardiol 11:129–135PubMedGoogle Scholar
  11. 11.
    Boubred F, Buffat C, Feuerstein JM, Daniel L, Tsimaratos M, Oliver C, Lelievre-Pegorier M, Simeoni U (2007) Effects of early postnatal hypernutrition on nephron number and long-term renal function and structure in rats. Am J Physiol Renal Physiol 293:F1944–F1949PubMedCrossRefGoogle Scholar
  12. 12.
    Chen H, Morris MJ (2009) Differential responses of orexigenic neuropeptides to fasting in offspring of obese mothers. Obesity (Silver Spring) 17:1356–1362Google Scholar
  13. 13.
    Bayne K (1996) Revised Guide for the Care and Use of Laboratory Animals available. Am Physiol Soc. Physiologist 39:199, 208–111Google Scholar
  14. 14.
    Bligh EG, Dyer WJ (1959) A rapid method of total lipid extraction and purification. Can J Biochem Physiol 37:911–917PubMedCrossRefGoogle Scholar
  15. 15.
    Lopes de Souza S, Orozco-Solis R, Grit I, Manhaes de Castro R, Bolanos-Jimenez F (2008) Perinatal protein restriction reduces the inhibitory action of serotonin on food intake. Eur J Neurosci 27:1400–1408PubMedCrossRefGoogle Scholar
  16. 16.
    Friedewald WT, Levy RI, Fredrickson DS (1972) Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem 18:499–502PubMedGoogle Scholar
  17. 17.
    Srinivasan M, Katewa SD, Palaniyappan A, Pandya JD, Patel MS (2006) Maternal high-fat diet consumption results in fetal malprogramming predisposing to the onset of metabolic syndrome-like phenotype in adulthood. Am J Physiol Endocrinol Metab 291:E792–E799PubMedCrossRefGoogle Scholar
  18. 18.
    Zambrano E, Bautista CJ, Deas M, Martinez-Samayoa PM, Gonzalez-Zamorano M, Ledesma H, Morales J, Larrea F, Nathanielsz PW (2006) A low maternal protein diet during pregnancy and lactation has sex- and window of exposure-specific effects on offspring growth and food intake, glucose metabolism and serum leptin in the rat. J Physiol 571:221–230PubMedCrossRefGoogle Scholar
  19. 19.
    Khan IY, Taylor PD, Dekou V, Seed PT, Lakasing L, Graham D, Dominiczak AF, Hanson MA, Poston L (2003) Gender-linked hypertension in offspring of lard-fed pregnant rats. Hypertension 41:168–175PubMedCrossRefGoogle Scholar
  20. 20.
    Tamashiro KL, Moran TH (2010) Perinatal environment and its influences on metabolic programming of offspring. Physiol Behav 100:560–566PubMedCrossRefGoogle Scholar
  21. 21.
    White CL, Purpera MN, Morrison CD (2009) Maternal obesity is necessary for programming effect of high-fat diet on offspring. Am J Physiol Regul Integr Comp Physiol 296:R1464–R1472PubMedCrossRefGoogle Scholar
  22. 22.
    Rodrigues AL, de Moura EG, Passos MC, Trevenzoli IH, da Conceicao EP, Bonono IT, Neto JF, Lisboa PC (2011) Postnatal early overfeeding induces hypothalamic higher SOCS3 expression and lower STAT3 activity in adult rats. J Nutr Biochem 22:109–117PubMedCrossRefGoogle Scholar

Copyright information

© AOCS 2011

Authors and Affiliations

  • Tchana Weyll Souza Oliveira
    • 1
  • Carol Góis Leandro
    • 2
    • 4
  • Tereza Cristina Bomfim de Jesus Deiró
    • 1
  • Gabriela dos Santos Perez
    • 1
  • Darlene da França Silva
    • 1
  • Janice Izabel Druzian
    • 3
  • Ricardo David Couto
    • 3
  • Jairza Maria Barreto-Medeiros
    • 1
  1. 1.Department of Food ScienceFederal University of BahiaSalvadorBrazil
  2. 2.Department of Physical Education and Sports ScienceCAV, Federal University of PernambucoRecifeBrazil
  3. 3.Departament of PharmacyFederal University of BahiaSalvadorBrazil
  4. 4.Universidade Federal de Pernambuco, Núcleo de Educação Física e Ciências do Esporte, Alto do ReservatórioVitória de Santo AntãoBrazil

Personalised recommendations