, Volume 46, Issue 11, pp 1071–1074 | Cite as

A Perinatal Palatable High-Fat Diet Increases Food Intake and Promotes Hypercholesterolemia in Adult Rats

  • Tchana Weyll Souza Oliveira
  • Carol Góis Leandro
  • Tereza Cristina Bomfim de Jesus Deiró
  • Gabriela dos Santos Perez
  • Darlene da França Silva
  • Janice Izabel Druzian
  • Ricardo David Couto
  • Jairza Maria Barreto-Medeiros


The main goal of the present study was to evaluate the long-term effects of a perinatal palatable high-fat diet on the food intake and cholesterol profile of adult rats. Male Wistar rats (aged 22 days) were divided into two groups according to their mother’s diet during gestation and lactation (C p, n = 10; pups from control mothers; and HLp n = 10; pups from mothers fed a palatable high-fat diet). At the 76th day, pups were housed individually for 14 days, and daily food consumption was determined during a period of 6 days. Blood from 100-day-old rats was sampled by cardiac puncture. Fasting (12 h) serum glucose, total cholesterol, LDL-C, HDL-C, triglycerides (TG), and VLDL-C levels were determined. The measurement of food intake was higher in the animals submitted to a hyperlipidic diet during the perinatal period. Serum total cholesterol, LDL-C, HDL-C, TG, VLDL-C and glycemia were increased in the HLp group compared to the control group. Our findings show that an early life environment with a high-fat diet can contribute to metabolic disease in later life.


Hyperlipidic diet Cholesterolemia Rats Developmental plasticity Critical period of development 



Control pups


Hyperlipid diet pups


High-density-lipoprotein cholesterol


Low-density-lipoprotein cholesterol


Monounsaturated fatty acids


Not detected


Polyunsaturated fatty acids


Saturated fatty acids


Trans fatty acids


Very-low-density-lipoprotein cholesterol



This study received financial support from the CNPq and FAPESB.


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Copyright information

© AOCS 2011

Authors and Affiliations

  • Tchana Weyll Souza Oliveira
    • 1
  • Carol Góis Leandro
    • 2
    • 4
  • Tereza Cristina Bomfim de Jesus Deiró
    • 1
  • Gabriela dos Santos Perez
    • 1
  • Darlene da França Silva
    • 1
  • Janice Izabel Druzian
    • 3
  • Ricardo David Couto
    • 3
  • Jairza Maria Barreto-Medeiros
    • 1
  1. 1.Department of Food ScienceFederal University of BahiaSalvadorBrazil
  2. 2.Department of Physical Education and Sports ScienceCAV, Federal University of PernambucoRecifeBrazil
  3. 3.Departament of PharmacyFederal University of BahiaSalvadorBrazil
  4. 4.Universidade Federal de Pernambuco, Núcleo de Educação Física e Ciências do Esporte, Alto do ReservatórioVitória de Santo AntãoBrazil

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