Lipids

, Volume 45, Issue 2, pp 129–135 | Cite as

Serum Phospholipid Transfer Protein Activity After a High Fat Meal in Patients with Insulin-Treated Type 2 Diabetes

  • Axel Schlitt
  • Bernhard Schwaab
  • Kirsten Fingscheidt
  • Karl J. Lackner
  • Gunnar H. Heine
  • Alexander Vogt
  • Michael Buerke
  • Lars Maegdefessel
  • Uwe Raaz
  • Karl Werdan
  • Xian-Cheng Jiang
Original Article

Abstract

Plasma phospholipid transfer protein (PLTP) mediates both net transfer and exchange of phospholipids between different lipoproteins. Animal studies have shown that it is closely related to the development of atherosclerosis. Although many studies have indicated that PLTP activity is increased in diabetes mellitus, the role of PLTP in diabetes is still unclear. To evaluate the influence of a high-fat meal on PLTP activity, 50 nondiabetic patients with coronary heart disease (CHD), 50 insulin-treated Type 2 diabetics, and 50 healthy controls were included. We determined PLTP activity before and 4 and 8 h after a high-fat meal. As expected, serum PLTP activity was significantly higher in CHD patients than in healthy controls (71.0 ± 46.2 vs. 54.0 ± 33.8 pmol/μl/h, P = 0.032) at baseline. More importantly, we found that serum PLTP activity increased to its maximum 4 h after fat loading and then decreased to nearly basal levels after 8 h both in controls and CHD patients. In contrast, PLTP activity continuously increased during this time period in the diabetic patients. With regards to the data from this study we hypothesize that serum PLTP is involved in the clearance of postprandial lipoproteins and this process is attenuated in diabetes. Since postprandial lipoproteins are atherogenic, the delay in clearance of these particles could play an important role in the development of atherosclerosis in patients with diabetes mellitus.

Keywords

Phospholipid transfer protein Diabetes mellitus 

Abbreviations

ACE

Angiotensin converting enzyme

BLp

ApoB-containing lipoprotein

CAD

Coronary artery disease

CHD

Coronary heart disease

CRP

C-reactive protein

HDL

High density lipoprotein

HDL-C

High density lipoprotein-cholesterol

OGTT

Oral glucose tolerance test

PLTP

Phospholipid transfer protein

RLP

Remnant-like particle

TG

Triglycerides

VLDL

Very low density lipoprotein

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Copyright information

© AOCS 2010

Authors and Affiliations

  • Axel Schlitt
    • 1
  • Bernhard Schwaab
    • 2
  • Kirsten Fingscheidt
    • 2
  • Karl J. Lackner
    • 3
  • Gunnar H. Heine
    • 4
  • Alexander Vogt
    • 1
  • Michael Buerke
    • 1
  • Lars Maegdefessel
    • 1
  • Uwe Raaz
    • 1
  • Karl Werdan
    • 1
  • Xian-Cheng Jiang
    • 5
  1. 1.Department of Medicine IIIMartin Luther-UniversityHalleGermany
  2. 2.Curschmann-ClinicTimmendorfer StrandGermany
  3. 3.Institute of Clinical Chemistry and Laboratory MedicineJohannes Gutenberg UniversityMainzGermany
  4. 4.Department of Medicine IVUniversity of the SaarlandHomburg/SaarGermany
  5. 5.Department of Anatomy and Cell BiologyDownstate Medical Center Brooklyn, State University of New YorkNew YorkUSA

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