, Volume 45, Issue 2, pp 129–135 | Cite as

Serum Phospholipid Transfer Protein Activity After a High Fat Meal in Patients with Insulin-Treated Type 2 Diabetes

  • Axel Schlitt
  • Bernhard Schwaab
  • Kirsten Fingscheidt
  • Karl J. Lackner
  • Gunnar H. Heine
  • Alexander Vogt
  • Michael Buerke
  • Lars Maegdefessel
  • Uwe Raaz
  • Karl Werdan
  • Xian-Cheng Jiang
Original Article


Plasma phospholipid transfer protein (PLTP) mediates both net transfer and exchange of phospholipids between different lipoproteins. Animal studies have shown that it is closely related to the development of atherosclerosis. Although many studies have indicated that PLTP activity is increased in diabetes mellitus, the role of PLTP in diabetes is still unclear. To evaluate the influence of a high-fat meal on PLTP activity, 50 nondiabetic patients with coronary heart disease (CHD), 50 insulin-treated Type 2 diabetics, and 50 healthy controls were included. We determined PLTP activity before and 4 and 8 h after a high-fat meal. As expected, serum PLTP activity was significantly higher in CHD patients than in healthy controls (71.0 ± 46.2 vs. 54.0 ± 33.8 pmol/μl/h, P = 0.032) at baseline. More importantly, we found that serum PLTP activity increased to its maximum 4 h after fat loading and then decreased to nearly basal levels after 8 h both in controls and CHD patients. In contrast, PLTP activity continuously increased during this time period in the diabetic patients. With regards to the data from this study we hypothesize that serum PLTP is involved in the clearance of postprandial lipoproteins and this process is attenuated in diabetes. Since postprandial lipoproteins are atherogenic, the delay in clearance of these particles could play an important role in the development of atherosclerosis in patients with diabetes mellitus.


Phospholipid transfer protein Diabetes mellitus 



Angiotensin converting enzyme


ApoB-containing lipoprotein


Coronary artery disease


Coronary heart disease


C-reactive protein


High density lipoprotein


High density lipoprotein-cholesterol


Oral glucose tolerance test


Phospholipid transfer protein


Remnant-like particle




Very low density lipoprotein


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Copyright information

© AOCS 2010

Authors and Affiliations

  • Axel Schlitt
    • 1
  • Bernhard Schwaab
    • 2
  • Kirsten Fingscheidt
    • 2
  • Karl J. Lackner
    • 3
  • Gunnar H. Heine
    • 4
  • Alexander Vogt
    • 1
  • Michael Buerke
    • 1
  • Lars Maegdefessel
    • 1
  • Uwe Raaz
    • 1
  • Karl Werdan
    • 1
  • Xian-Cheng Jiang
    • 5
  1. 1.Department of Medicine IIIMartin Luther-UniversityHalleGermany
  2. 2.Curschmann-ClinicTimmendorfer StrandGermany
  3. 3.Institute of Clinical Chemistry and Laboratory MedicineJohannes Gutenberg UniversityMainzGermany
  4. 4.Department of Medicine IVUniversity of the SaarlandHomburg/SaarGermany
  5. 5.Department of Anatomy and Cell BiologyDownstate Medical Center Brooklyn, State University of New YorkNew YorkUSA

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