Effects of Weight Loss on Lipid Transfer Proteins in Morbidly Obese Women
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Obesity is associated with lipid abnormalities leading to an increased morbidity and mortality from atherosclerotic disease. Lipid transfer proteins such as Cholesteryl Ester Transfer Protein (CETP) and Phospholipid Transfer Protein (PLTP), and lipases such as lipoprotein lipase (LPL) and hepatic lipase (HL) are involved in the pathogenesis of the obesity associated proatherogenic dyslipidemia. Nineteen severely obese female subjects undergoing laparosopic gastric banding participated in this prospective study. Subjects were examined with respect to body composition, lipid profile, CETP, PLTP, LPL and HL before and 1 year after surgical treatment. Mean weight loss was 22.2 kg, mainly due to losses in the fat depots. Triglycerides decreased and HDL2-C increased significantly. In respect to transfer proteins mean CETP mass decreased from 1.82 to 1.71 μg mL−1 (P = 0.043) and mean PLTP activity was reduced from 7.15 to 6.12 μmol mL−1 h−1 (P = 0.002), in parallel. In addition, both mean LPL activity and mean HL activity tended to decrease from 297 to 248 nmol mL−1 h−1 for LPL (P = 0.139) and from 371 to 319 nmol mL−1 h−1 for HL (P = 0.170), respectively. We conclude that weight loss induced by bariatric surgery is associated with the amelioration of the obesity-associated dyslipidemic state. This improvement may be attributable to decreased mass and action of the adipocyte tissue derived lipid transfer proteins CETP and PLTP.
KeywordsWeight loss Cholesteryl ester transfer protein Hepatic lipase Lipids Lipoprotein lipase Phospholipid transfer protein
Cholesteryl ester transfer protein
High density lipoprotein
Laparoscopic adjustable gastric banding
Low density lipoprotein
Phospholipid transfer protein
Very low-density lipoprotein
The expert technical assistance of Ursula Stanzl and Karin Salzmann is gratefully acknowledged.
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