Lipids

, Volume 43, Issue 9, pp 805–811

Stearidonic Acid-Enriched Soybean Oil Increased the Omega-3 Index, an Emerging Cardiovascular Risk Marker

  • William S. Harris
  • Shawna L. Lemke
  • Susan N. Hansen
  • Daniel A. Goldstein
  • Maureen A. DiRienzo
  • Hong Su
  • Margaret A. Nemeth
  • Mary L. Taylor
  • Gulam Ahmed
  • Cherian George
Original Article

Abstract

A plant source of omega-3 fatty acid (FA) that can raise tissue eicosapentaenoic acid (EPA) and/or docosahexaenoic acid (DHA) is needed. A soybean oil (SBO) containing approximately 20% stearidonic acid [SDA; the delta-6 desaturase product of alpha-linolenic acid (ALA)] derived from genetically modified soybeans is under development. This study compared the effects of EPA to SDA-SBO on erythrocyte EPA + DHA levels (the omega-3 index). Overweight healthy volunteers (n = 45) were randomized to SDA-SBO (24 ml/day providing ~3.7 g SDA) or to regular SBO (control group) without or with EPA ethyl esters (~1 g/day) for 16 weeks. Serum lipids, blood pressure, heart rate, platelet function and safety laboratory tests were measured along with the omega-3 index. A per-protocol analysis was conducted on 33 subjects (11 per group). Compared to baseline, average omega-3 index levels increased 19.5% in the SDA group and 25.4% in the EPA group (p < 0.05 for both, vs. control). DHA did not change in any group. Relative to EPA, SDA increased RBC EPA with about 17% efficiency. No other clinical endpoints were affected by SDA or EPA treatment (vs. control). In conclusion, SDA-enriched SBO significantly raised the omega-3 index. Since EPA supplementation has been shown to raise the omega-3 index and to lower risk for cardiac events, SDA-SBO may be a viable plant-based alternative for providing meaningful intakes of cardioprotective omega-3 FAs.

Keywords

Omega-3 fatty acids Stearidonic acid Cardiovascular disease Risk factors Soybean oil Genetically modified organisms 

Supplementary material

11745_2008_3215_MOESM1_ESM.doc (294 kb)
MOESM1 (DOC 294 kb)

Copyright information

© AOCS 2008

Authors and Affiliations

  • William S. Harris
    • 1
  • Shawna L. Lemke
    • 2
  • Susan N. Hansen
    • 1
  • Daniel A. Goldstein
    • 2
  • Maureen A. DiRienzo
    • 2
  • Hong Su
    • 2
  • Margaret A. Nemeth
    • 2
  • Mary L. Taylor
    • 2
  • Gulam Ahmed
    • 2
  • Cherian George
    • 2
  1. 1.Sanford Research/USDSioux FallsUSA
  2. 2.Product Safety Center, Monsanto CompanySt LouisUSA

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