Lipids

, Volume 41, Issue 2, pp 207–212 | Cite as

Lower weight gain and higher expression and blood levels of adiponectin in rats fed medium-chain TAG compared with long-chain TAG

  • Hiroyuki Takeuchi
  • Osamu Noguchi
  • Seiji Sekine
  • Aiko Kobayashi
  • Toshiaki Aoyama
Communication

Abstract

Previous studies demonstrated that, compared with long-chain TAG (LCT), dietary medium-chain TAG (MCT) could improve glucose tolerance in rats and humans. It has been well established that adiponectin acts to increase insulin sensitivity. The effects of dietary MCT on adiponectin serum concentration and mRNA levels in adipose tissue were studied in rats. Male Spague-Dawley rats were feda diet containing 20% MCT or LCT for 8 wk. After 6 wk of dietary treatment, an oral glucose tolerance test was performed. Rats fed the MCT diet had less body fat accumulation than those fed the LCT diet (P<0.01). The cell diameter of the perirenal adipose tissue, one of the abdominal adipose tissues, was smaller (P<0.01) in the MCT diet group. The serum adiponectin concentration was higher (P<0.01) in the MCT diet group than in the LCT diet group. The adiponectin content in the perirenal adipose tissue was higher (P<0.01) in the MCT diet group. The MCT-fed group had a higher adiponectin mRNA level in their perirenal adipose tissue (P<0.05). The increase of the plasma glucose concentration after glucose administration istration (area under the curve) was smaller (P<0.01) in the MCT diet group than in the LCT diet group. These findings suggest that dietary MCT, compared with LCT, results in a higher serum adiponectin level with trascriptional activation of the adiponectin gene in rats. We speculate that improved lucose tolerance in rats fed an MCT diet may be, at least in part, ascribed to this higher serum adiponectin level.

Abbreviations

AUC

area under the curve

CBP

cAMP response element binding-protein binding protein

CREB

cAMP response element bindingprotein

LCT

long-chain TAG

LRH-I

liver receptor homolog-I

MCT

medium-chain TAG

PPARγ

peroxisome proliferator-activated receptorγ

PPRE

peroxisome proliferator-activated receptor-responsive element

RXR

retinoid X receptor

RT

reverse transcription

TNF-α

tumor necrosis factor

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Copyright information

© AOCS Press 2006

Authors and Affiliations

  • Hiroyuki Takeuchi
    • 1
  • Osamu Noguchi
    • 1
  • Seiji Sekine
    • 1
  • Aiko Kobayashi
    • 1
  • Toshiaki Aoyama
    • 1
  1. 1.Division of Healthcare Science. Research LaboratoryNisshin Oillio Group IKanagawaJapan

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