Lipids

, Volume 42, Issue 2, pp 117–122

A Docosahexaenoic Acid-Functional Food During Pregnancy Benefits Infant Visual Acuity at Four but not Six Months of Age

  • Michelle P. Judge
  • Ofer Harel
  • Carol J. Lammi-Keefe
Original Article

Abstract

Within the visual system, docosahexaenoic acid (DHA, 22:6n−3) is an important structural component for retinal photoreceptors and cortical gray matter. There is a marked decrease in neural DHA accumulation in the face of DHA deficiency. DHA is accumulated at an accelerated rate during pregnancy, especially in the third trimester. However, pregnant women in the US and Canada have dietary DHA intakes that are significantly below the optimal level. The main objective of this study was to determine whether a DHA-functional food during pregnancy would benefit infant visual acuity at four and six months of age measured behaviorally using the acuity card procedure (ACP). In a randomized, longitudinal, double-blinded, and placebo-controlled trial, 30 pregnant women received either the DHA-functional food (n = 16) or the placebo (n = 14). There were significant main effects for visual acuity at four months of age (P = 0.018). The mean acuity scores were 3.8 ± 1.1 cycles/degree in the DHA group versus 3.2 ± 0.7 cycles/degree in the placebo group. At six months there were no group differences. Based on our results, we conclude that DHA supplemented during pregnancy plays a role in the maturation of the visual system.

Keywords

Visual acuity Infant visual development Docosahexaenoic acid Pregnancy Functional food 

References

  1. 1.
    Neuringer M (2000) Infant vision and retinal function in studies of dietary long-chain polyunsaturated fatty acids: methods, results and implications. Am J Clin Nutr 71:256S–267SPubMedGoogle Scholar
  2. 2.
    Salomao SR, Ventura DF (1995) Large sample population age norms for visual acuities obtained with vistech-teller acuity cards. Invest Opthalmol Vis Sci 36:657–670Google Scholar
  3. 3.
    Neuringer M, Connor WE, Barstad L, Luck S (1986) Biochemical and functional effects of prenatal and postnatal n−3 fatty acid deficiency on retina and brain in rhesus monkeys. Proc Natl Acad Sci 83:4021–4025PubMedCrossRefGoogle Scholar
  4. 4.
    Carlson SE, Ford AJ, Werkman SH, Peeples JM, Koo WK (1996) Visual acuity and fatty acid status of term infants fed human milk and formulas with and without docosahexaenoate and arachidonate from egg yolk lecithin. Pediatr Res 39:882–888PubMedGoogle Scholar
  5. 5.
    Jorgensen HM, Hernell O, Lund P, Holmer G, Michaelsen KF (1996) Visual acuity and erythrocyte docosahexaenoic acid status in breast-fed and formula-fed term infants during the first four months of life. Lipids 31:99–105PubMedCrossRefGoogle Scholar
  6. 6.
    Birch E, Birch DG, Hoffman DR, Hale L, Everett M, Uauy RD (1993) Breast feeding and optimal visual development. J Pediatr Ophthalmol Strabismus 30:33–38PubMedGoogle Scholar
  7. 7.
    Hoffman DR, Birch EE, Castaneda YS, Fawcett SL, Wheaton DH, Birch DG, Uauy R (2003) Visual function in breast-fed term infants weaned to formula with or without long-chain polyunsaturates at 4 to 6 months: a randomized clinical trial. J Pediatr 142:669–677PubMedCrossRefGoogle Scholar
  8. 8.
    Makrides M, Simmer K, Goggin M, Gibson RA (1993) Erythrocyte docosahexaenoic acid correlates with the visual response of healthy, term infants. Pediatr Res 33:425–427PubMedCrossRefGoogle Scholar
  9. 9.
    Makrides M, Neumann M, Simmer K, Pater J, Gibson R (1995) Are long-chain polyunsaturated fatty acids essential nutrients in infancy? Lancet 345:1463–1468PubMedCrossRefGoogle Scholar
  10. 10.
    Malcolm CA, McCulloch DL, Montgomery C, Shepherd A, Weaver LT (2003) Maternal docosahexaenoic acid supplementation during pregnancy and visual evoked potential development in term infants: a double blind, prospective, randomized trial. Arch Dis Childhood Fetal Neonatal Ed 88:F383–F390CrossRefGoogle Scholar
  11. 11.
    Malcolm CA, Hamilton R, McCulloch DL, Montgomery C, Weaver LT (2003) Scotopic electroretinogram in term infants born of mothers supplemented with docosahexaenoic acid during pregnancy. Invest Opthalmol Vis Sci 44:3685–3691CrossRefGoogle Scholar
  12. 12.
    Simopoulos AP, Leaf A, Salem N (2000) Workshop statement on the essentiality and recommended dietary intakes for omega-6 and omega-3 fatty acids. Prostaglandins Leukot Essent Fatty Acids 83:119–21Google Scholar
  13. 13.
    Lewis NM, Widga AC, Buck JS, Frederick AM (1995) Survey of omega-3 fatty acids in diets of midwest low-income pregnant women. J Agromed 2:49–56CrossRefGoogle Scholar
  14. 14.
    Judge MP, Loosemore ED, DeMare CI, Keplinger MR, Mutungi G, Cote S, Ryan M, Ibarolla B, Lammi-Keefe CJ (2003) Dietary docosahexaenoic acid (DHA) intake in pregnant women. J Am Diet Assoc 103:A82Google Scholar
  15. 15.
    Judge MP, Loosemore ED, Farkas SL, DeMare CI, Keplinger MR, Mutungi G, Cote S, Ryan M, Ibarolla B, Lammi-Keefe CJ (2003) Dietary DHA intake across four ethnic groups. FASEB J 17:71–72Google Scholar
  16. 16.
    Innis SM, Elias SL (2003) Intakes of essential n−6 and n−3 polyunsaturated fatty acids among pregnant Canadian women. Am J Clin Nutr 77:473–478PubMedGoogle Scholar
  17. 17.
    Denomme J, Stark KD, Holub BJ (2005) Directly quantitated dietary (n−3) fatty acid intakes of pregnant Canadian women are lower than current dietary recommendations. J Nutr 135:206–211PubMedGoogle Scholar
  18. 18.
    Teller D (1990) Teller acuity cards (Tac) manual. Vistech Consultants, Inc., Dayton, OHGoogle Scholar
  19. 19.
    Hartmann EE, Ellis GS, Morgan KS, Love A, May JG (1990) The acuity card procedure: longitudinal assessments. J Pediatr Opthalmol Strabismus 27:184–187Google Scholar
  20. 20.
    Mayer LD, Dobson V (1997) Grating acuity cards: validity and reliability in studies of human visual development. Academic, New York, pp 253–292Google Scholar
  21. 21.
    Freund RJ, Littell RD, Spector PC (2003) SAS System, v9 (TS M0). SAS Institute, Inc., Cary, NCGoogle Scholar
  22. 22.
    Nui SL, Mitchell DC, Lim SY, Wen ZM, Kim HY, Salem N, Litman BJ (2004) Reduced G protein-coupled signaling efficiency in retinal rod outer segments in response to n−3 fatty acid deficiency. J Biol Chem 279:31098–31104CrossRefGoogle Scholar
  23. 23.
    Salem N Jr, Litman B, Kim HY, Gawrisch K (2001) Mechanisms of action of docosahexaenoic acid in the nervous system. Lipids 36:945–959PubMedCrossRefGoogle Scholar
  24. 24.
    Neuringer M, Jeffrey BG (2003) Visual development: neural basis and new assessment methods. J Pediatr 143:S87–S95PubMedCrossRefGoogle Scholar

Copyright information

© AOCS 2007

Authors and Affiliations

  • Michelle P. Judge
    • 1
  • Ofer Harel
    • 2
  • Carol J. Lammi-Keefe
    • 1
    • 3
  1. 1.Department of Nutritional SciencesUniversity of ConnecticutStorrsUSA
  2. 2.Department of StatisticsUniversity of ConnecticutStorrsUSA
  3. 3.Division of Human Nutrition and FoodLouisiana State University, School of Human Ecology and Pennington Biomedical Research CenterBaton RougeUSA

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