n−3 long-chain FA decrease serum levels of TG and remnant-like particle-cholesterol in humans
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A large number of papers have reported that administration of n−3 FA reduced serum TG concentrations in hypertriglyceridemic patients. However, few studies have examined the effect of n−3 FA on serum concentrations of remnant-like particle (RLP) cholesterol. Volunteers (n=41) whose serum TG concentrations were 100–300 mg/dL were recruited and randomly assigned to either an n−3 FA group or a control group with stratification by sex, age, and serum TG level in a double-blind manner. The subjects in the n−3 FA group were administered 125 ml of fermented soybean milk with fish oil containing 600 mg of EPA and 260 mg of DHA/d for 12 wk. The controls consumed control soybean milk with olive oil. Fasting blood samples were obtained before the start of administration and at 4, 8 and 12 wk. EPA concentrations in red blood cells increased significantly in all but one subject in the n−3 FA group, with no significant changes in the control group. TG levels decreased more in the n−3 FA group than in the control group at weeks 4 (P<0.05), 8 (P<0.01), and 12 (P<0.05) with their baseline as covariate. RLP cholesterol levels decreased more in the n−3 FA group than in the control at weeks 8 (P<0.01) and 12 (P<0.05) with their baseline as covariate. The groups did not differ in the other lipid levels. It is likely that n−3 long-chain FA may exert anti-atherosclerotic effects by lowering serum TG and RLP-cholesterol levels even at the dose of 860 mg/d.
red blood cells
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- 1.Smith, S.C., Jr., Blair, S.N., Bonow, R.O., Brass, L.M., Cerqueira, M.D., Dracup, K., Fuster, V., Gotto, A., Grundy, S.M., Miller, N.H., et al. (2001) AHA/ACC Scientific Statement: AHA/ACC Guidelines for Preventing Heart Attack and Death in Patients with Atherosclerotic Cardiovascular Disease: 2001 Update: A Statement for Healthcare Professionals from the American Heart Association and the American College of Cardiology, Circulation 104, 1577–1579.PubMedGoogle Scholar
- 3.Singh, R.B., Niaz, M.A., Sharma, J.P., Kumar, R., Rastogi, V., and Moshiri, M. (1997) Randomized, Double-Blind, Placebo-Controlled Trial of Fish Oil and Mustard Oil in Patients with Suspected Acute Myocardial Infarction: The Indian Experiment of Infarct Survival—4, Cardiovasc. Drugs Ther. 11, 485–491.CrossRefPubMedGoogle Scholar
- 9.Nakamura, N., Hamazaki, T., Ohta, M., Okuda, K., Urakaze, M., Sawazaki, S., Yamazaki, K., Satoh, A., Temaru, R., Ishikura, Y., et al. (1999) Joint Effects of HMG-CoA Reductase Inhibitors and Eicosapentaenoic Acids on Serum Lipid Profile and Plasma Fatty Acid Concentations in Patients with Hyperlipidemia, Int. J. Clin. Lab. Res. 29, 22–25.CrossRefPubMedGoogle Scholar
- 16.Tamaoku, K., Ueno, K., Akiura, K., and Ohkuma, Y. (1982) New Water-Soluble Hydrogen Donors for the Enzymatic Photometric Detemrination of Hydrogen Peroxide. II. N-Ethyl-N-(2-hydroxy-3-sulfopropyl) Aniline Derivatives, Chem. Pharm. Bull. 30, 2492–2497.Google Scholar
- 18.Nakajima, K., Saito, T., Tamura, A., Suzuki, M., Nakano, T., Adachi, M., Tanaka, A., Tada, N., Nakamura, H., Campos, E., et al. (1993) Cholesterol in Remnant-Like Lipoproteins in Human Serum Using Monoclonal Anti ApoB-100 and Anti ApoA-I Immunoaffinity Mixed Gels, Clin. Chim. Acta 223, 53–71.CrossRefPubMedGoogle Scholar
- 19.Nakajima, K., Okazaki, M., Tanaka, A., Pullinger, C.R., Wang, T., Nakano, T., Adachi, M., and Havel, R.J. (1996) Separation and Determination of Remnant-Like Particles in Human Serum Using Monoclonal Antibodies to ApoB-100 and ApoA-1, J. Clin. Lignand Assay 19, 177–183.Google Scholar
- 22.Higgins, S., Carroll, Y.L., McCarthy, S.N., Corridan, B.M., Roche, H.M., Wallace, J.M., O'Brien, N.M., and Morrissey, P.A. (2001) Susceptibility of LDL to Oxidative Modification in Healthy Volunteers Supplemented with Low Doses of n−3 Polyunsaturated Fatty Acids, Br. J. Nutr. 85, 23–31.PubMedGoogle Scholar
- 23.Takanami, Y., and Shimomitsu, T. (1999) Mild Exercise Training Is an Effective Therapy to Reduce the Serum Remnant-Like Particles in Subjects with High Remnants Despite the Lack of Weight of Body Fat Loss, Circulation 100 (Suppl.), I-822.Google Scholar
- 27.McNamara, J.R., Shah, P.K., Nakajima, K., Cupples, L.A., Wilson, P.W., Ordovas, J.M., and Schaefer, E.J. (2001) Remnant-Like Particle (RLP) Cholesterol Is an Independent Cardiovascular Disease Risk Factor in Women: Results from the Framingham Heart Study, Atherosclerosis 154, 229–236.CrossRefPubMedGoogle Scholar