, Volume 38, Issue 4, pp 353–358 | Cite as

n−3 long-chain FA decrease serum levels of TG and remnant-like particle-cholesterol in humans

  • Kei Hamazaki
  • Miho Itomura
  • Mingming Huan
  • Hiroto Nishizawa
  • Shiro Watanabe
  • Tomohito Hamazaki
  • Shigeki Sawazaki
  • Katsutoshi Terasawa
  • Shuuji Nakajima
  • Takashi Terano
  • Yoshiya Hata
  • Seiichi Fujishiro


A large number of papers have reported that administration of n−3 FA reduced serum TG concentrations in hypertriglyceridemic patients. However, few studies have examined the effect of n−3 FA on serum concentrations of remnant-like particle (RLP) cholesterol. Volunteers (n=41) whose serum TG concentrations were 100–300 mg/dL were recruited and randomly assigned to either an n−3 FA group or a control group with stratification by sex, age, and serum TG level in a double-blind manner. The subjects in the n−3 FA group were administered 125 ml of fermented soybean milk with fish oil containing 600 mg of EPA and 260 mg of DHA/d for 12 wk. The controls consumed control soybean milk with olive oil. Fasting blood samples were obtained before the start of administration and at 4, 8 and 12 wk. EPA concentrations in red blood cells increased significantly in all but one subject in the n−3 FA group, with no significant changes in the control group. TG levels decreased more in the n−3 FA group than in the control group at weeks 4 (P<0.05), 8 (P<0.01), and 12 (P<0.05) with their baseline as covariate. RLP cholesterol levels decreased more in the n−3 FA group than in the control at weeks 8 (P<0.01) and 12 (P<0.05) with their baseline as covariate. The groups did not differ in the other lipid levels. It is likely that n−3 long-chain FA may exert anti-atherosclerotic effects by lowering serum TG and RLP-cholesterol levels even at the dose of 860 mg/d.





long-chain PUFA


red blood cells


remnant-like particle


Special Reference Laboratories


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Copyright information

© AOCS Press 2003

Authors and Affiliations

  • Kei Hamazaki
    • 1
  • Miho Itomura
    • 1
  • Mingming Huan
    • 1
  • Hiroto Nishizawa
    • 1
  • Shiro Watanabe
    • 1
  • Tomohito Hamazaki
    • 1
  • Shigeki Sawazaki
    • 2
  • Katsutoshi Terasawa
    • 3
  • Shuuji Nakajima
    • 4
  • Takashi Terano
    • 5
  • Yoshiya Hata
    • 6
  • Seiichi Fujishiro
    • 7
  1. 1.Department of Clinical Application, Institute of Natural MedicineToyama Medical and Pharmaceutical UniversityToyama-shi, ToyamaJapan
  2. 2.First Department of Internal MedicineToyama Medical and Pharmaceutical UniversityToyama-shi ToyamaJapan
  3. 3.Department of Japanese Oriental Medicine, Faculty of MedicineToyama Medical and Pharmaceutical UniversityToyama-shi, ToyamaJapan
  4. 4.Fine Chemicals DepartmentNippon Suisan Kaisha, Ltd.TokyoJapan
  5. 5.Chiba City HospitalChibaJapan
  6. 6.Department of Medicine and GerontologyKyourin University School of MedicineTokyoJapan
  7. 7.Department of PharmacyNarutou General HospitalChibaJapan

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