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Effect of a low-fat diet enriched with oleic acid on postprandial lipemia in patients with type 2 diabetes mellitus

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Lipids

Abstract

The aim of the present study was to compare the effects of a low-fat diet enriched with oleic acid to those of a low-fat diet enriched with linoleic acid on fasting lipids, postprandial lipemia, and oxidative susceptibility of low-density lipoprotein (LDL) in patients with type 2 diabetes mellitus (DM). In a 3-wk randomized crossover study, eight patients with type 2 DM were given an experimental low-fat diet enriched with either oleic acid or linoleic acid. The oleic-acid-enriched diet contained 5, 15, and 5% energy from saturated, monounsaturated, and polyunsaturated fatty acids, and the linoleic-acid-enriched diet contained 5, 5, and 15% energy from saturated, monounsaturated, and polyunsaturated fatty acids, respectively. In addition to evaluating the fasting lipids and oxidative susceptibility of LDL, we evaluated postprandial lipemia using an oral fat load at the end of each 3-wk dietary phase. There were no significant differences in fasting lipid profile or lag time of LDL oxidation between the two experimental dietary phases. The average and maximal increments of remnant-like particle (RLP) cholesterol levels during oral fat load were significantly higher after the oleic-acid-enriched dietary phase than after the linoleic-acid-enriched dietary phase. The area under the curve of RLP cholesterol was also significantly larger after the oleicacid-enriched dietary phase than after the linoleic-acid-enriched dietary phase. These results suggest that the oleic-acidenriched diet was associated with increased formation of postprandial chylomicron remnants compared with the linoleicacid-enriched diet.

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Abbreviations

apo:

apolipoprotein

AUC:

area under the curve

CHD:

coronary heart disease

DM:

diabetes mellitus

FFA:

free fatty acid

HDL:

high density lipoprotein

HPLC:

high-performance liquid chromatography

LDL:

low density lipoprotein

LPL:

lipoprotein lipase

LPO:

lipid peroxidation

PBS:

phosphate-buffered saline

RLP:

remnant-like particles

TG:

triglyceride

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Authors and Affiliations

  1. SONY Wellness Center, SONY Corporation, Shinagawa, Tokyo, Japan

    Toshitsugu Ishikawa

  2. Mitsukoshi Health and Welfare Foundation, Shinjuku, Tokyo, Japan

    Haruo Nakamura

  3. First Department of Internal Medicine, National Defense Medical College, 3-2 Namiki, tokorozawa, 359-0042, Saitama, Japan

    Kenji Higashi, Hideki Shige, Toshimitsu Ito, Kei Nakajima & Fumitaka Ohsuzu

Authors
  1. Kenji Higashi
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  2. Hideki Shige
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  3. Toshimitsu Ito
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  4. Kei Nakajima
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  5. Toshitsugu Ishikawa
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  6. Haruo Nakamura
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  7. Fumitaka Ohsuzu
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Correspondence to Kenji Higashi.

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Higashi, K., Shige, H., Ito, T. et al. Effect of a low-fat diet enriched with oleic acid on postprandial lipemia in patients with type 2 diabetes mellitus. Lipids 36, 1–6 (2001). https://doi.org/10.1007/s11745-001-0660-5

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  • DOI: https://doi.org/10.1007/s11745-001-0660-5

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