Abstract
Simple economical syntheses in good yield of octa-, nona-, and undecaethylene glycols were developed based on a coupling methodology whereby monobenzyl trior tetraethylene glycols were chain-extended either by coupling them together in the presence of tosyl chloride or through reaction with α,ω-ditosyl triethylene glycol in dioxane in the presence of powdered KOH. The α,ω-O-benzyl-protecting groups were removed by catalytic hydrogenolysis.
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Zada, A., Avny, Y. & Zilkha, A. Simplified synthesis of oligoethylene glycols. J Surfact Deterg 4, 163–166 (2001). https://doi.org/10.1007/s11743-001-0170-8
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DOI: https://doi.org/10.1007/s11743-001-0170-8