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Internal and Emergency Medicine

, Volume 14, Issue 8, pp 1353–1356 | Cite as

Direct oral anticoagulants in factor VII deficiency patient

  • Fulvio PomeroEmail author
  • Laura Spadafora
  • Salvatore D’Agnano
  • Francesco Dentali
  • Luigi Maria Fenoglio
CE - Research Letter to the Editor
  • 66 Downloads

Dear Sir,

Factor VII (FVII) is a vitamin K-dependent coagulation factor synthesized in the liver which plays a major role in the coagulation extrinsic pathway which is initiated at tissue damage sites, following the formation of a complex between activated FVII (FVIIa) and tissue factor. Plasma levels range around 0.35–0.60 mg/L (for a normal coagulant activity comprised between 70 and 140%), which is 10 times less than other vitamin K-dependent factors. Its half-life is extremely short (4–6 h) [ 1]. Inherited FVII deficiency, with an estimated prevalence of 1:300,000 population in European countries, is the most common among the rare congenital coagulation disorders, characterized by autosomal recessive inheritance. As with other forms of hemophilia, FVII deficiency can also be caused by medications such as vitamin K antagonists (VKA), medical conditions or malabsorption [ 2, 3]. Suspicion of FVII deficiency arises in presence of a reduced FVII coagulant activity (FVII:C), a prolonged...

Notes

Acknowledgements

The authors received no financial support for the research, authorship, and/or publication of this article.

Compliance with ethical standards

Conflict of interests

The authors state that they have no conflict of interest.

Statement of human and animal rights

This article does not contain any studies with animals performed by any of the authors. All procedures performed were in accordance with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. As the case report is retrospective, discussion in the Ethics Committee was waived.

Informed consent

Informed consent was obtained from the patient included in the study.

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Copyright information

© Società Italiana di Medicina Interna (SIMI) 2019

Authors and Affiliations

  1. 1.U.O. Medicina InternaOspedale S. LazzaroAlbaItaly
  2. 2.Emergency DepartmentS. Paolo HospitalSavonaItaly
  3. 3.Specialty Training in Internal MedicineUniversity of TurinTurinItaly
  4. 4.Department of Clinical MedicineUniversity of InsubriaVareseItaly
  5. 5.Department of Internal MedicineASO S. Croce E CarleCuneoItaly

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