Internal and Emergency Medicine

, Volume 14, Issue 8, pp 1299–1306 | Cite as

Prevalence and prognostic impact of left ventricular non-compaction in patients with thalassemia

  • Rodolfo Bonamini
  • Massimo ImazioEmail author
  • Riccardo Faletti
  • Marco Gatti
  • Borejda Xhyheri
  • Marco Limone
  • Filomena Longo
  • Antonio Piga


A high incidence of isolated left ventricular non-compaction (LVNC) has been reported in previous studies on smaller cohorts of patients with thalassemia by cardiac MRI but the clinical impact of the finding is unknown. This prospective cohort study evaluates the prevalence and clinical implication of the finding. Prospective cohort study with enrollment of all consecutive cases with thalassemia referred for cardiac MRI from September 2007 to November 2014. The presence of LVNC was assessed according to the Petersen method and the Jacquier method, with the proposed changes by Fazio, Grothoff, and Chiodi. A clinical follow-up was performed in all patients. We included 560 patients with thalassemia (473 with thalassemia major and 87 with thalassemia intermedia: mean age 31.9 ± 10.6 years, male/female = 250/310). A total number of 1683 MRI tests were performed. A diagnosis of LVNC was determined according to adopted MR criteria in 44 patients (7.9%). Patients with LVNC had a significantly lower ejection fraction (52.68 ± 5.17% vs. 56.90 ± 6.34%; p = 0.0005) and greater indexed LV ESV (48.16 ± 10.03 ml/m2 vs. 40.02 ± 10.06 ml/m2; p = 0.0022). After a mean follow-up time was 5.1 years, no significant change of MR parameters was detected as well as no clinical adverse events. LVNC is relatively frequent in patients with thalassemia. However, it is not associated with a worsening of LV function and adverse events after a long-term follow-up.


Thalassemia Left ventricular non-compaction Cardiac magnetic resonance Prognosis 


Compliance with ethical standards

Conflict of interest

The author(s) declare that they have no conflict of interest.

Statement of human and animal rights

The study complies with the declaration of Helsinki.

Informed consent

Patient had informed signed consent before the CMR study.


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Copyright information

© Società Italiana di Medicina Interna (SIMI) 2019

Authors and Affiliations

  1. 1.Department of Surgical Sciences, Radiology UnitUniversity of TorinoTurinItaly
  2. 2.University Cardiology, AOU Città Della Salute e Della Scienza Di TorinoTurinItaly
  3. 3.Nuovo Ospedale Degli InfermiPonderanoItaly
  4. 4.Department of Clinical and Biological SciencesUniversity of TorinoTurinItaly
  5. 5.Reference Centre for HemoglobinopathiesAOU San Luigi Gonzaga HospitalOrbassanoItaly

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