Daylight saving time transitions and circulatory deaths: data from the Veneto region of Italy

  • Roberto ManfrediniEmail author
  • Fabio Fabbian
  • Alfredo De Giorgi
  • Rosaria Cappadona
  • Giulia Capodaglio
  • Ugo Fedeli

Dear Sir,

Living organisms are characterized by circadian mechanisms. The central circadian clock is located within the suprachiasmatic nucleus of the hypothalamus, and peripheral clocks have also been widely found across organisms. Such complex machinery allows living organisms to synchronize and optimally adapt to either their external or their internal environments [1]. On the other hand, circadian misalignment of an organism with its environment may increase cardiovascular risk factors and lead to the development of cardiovascular (CV) diseases [2]. Daylight saving time (DST), which was adopted during the First World War to save energy and is still in use in many countries worldwide, can be a cause of circadian misalignment. Based on concerns about human health, Finland and other northern state members called for the abolition of DST, and a proposal by the European Commission to discontinue the bi-annual shifts has been recently approved by the European Parliament.

We aimed to...


Chronobiology Circadian rhythm Daylight saving time Cardiovascular disease Cerebrovascular disease Death Epidemiology ICD-9-CM codes 



We are grateful to Dr Claudia Righini, Dr Donato Bragatto, and the staff of the Biblioteca Interaziendale di Scienze della Salute, Azienda Ospedaliera-Universitaria ‘S.Anna’, Ferrara, for their continuous support. We would like to acknowledge the professional manuscript services of American Journal Experts.


This work was supported, in part, by a research grant “Fondo Incentivazione Ricerca—FIR 2018”, University of Ferrara, Italy (prof. Roberto Manfredini).

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest regarding the publication of this work.

Statement of human and animal rights

This article does not contain any studies with human participants or animals performed by any of the authors.

Informed consent



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Copyright information

© Società Italiana di Medicina Interna (SIMI) 2019

Authors and Affiliations

  1. 1.Faculty of Medicine, Pharmacy and PreventionUniversity of FerraraFerraraItaly
  2. 2.Epidemiological DepartmentPaduaItaly

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