Is vitamin D deficiency predictor of complications development in patients with HCV-related cirrhosis?

  • Anna LicataEmail author
  • Maria Giovanna Minissale
  • Filippo A. Montalto
  • Maurizio Soresi

Around 130–170 million people in the world, according to WHO estimates, are infected with hepatitis C virus (HCV), with a wide variability in geographical distribution [1]. HCV causes both acute and chronic hepatitis, the latter evolving to cirrhosis with impairment of liver structure and function, development of fibrosis, portal hypertension and hyperdinamic circulation [2]. During this progression, the varying degree of fibrosis can be assessed through non-invasive serological tests and/or imaging techniques, which have been proposed as reliable indicators [3]. Clinical complications of cirrhosis are esophageal varices, ascites with spontaneous bacterial peritonitis, hepato-renal syndrome, hepato-pulmunary syndrome and hepatic encephalopathy [4, 5].

Vitamin D is a secosteroid hormone which is involved in several processes [6]. It has pleiotropic effects being mainly implicated in bone and calcium homeostasis, cardiovascular system function, pancreatic endocrine cells, muscle and...


Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Statement of human and animal rights

As Commentary this article does not contain any studies with human participants or animals performed by any of the authors.

Informed consent

Informed consent was obtained from all individual participants included in the study.


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Copyright information

© Società Italiana di Medicina Interna (SIMI) 2019

Authors and Affiliations

  1. 1.Medicina Interna ed Epatologia, Dipartimento di Promozione della Salute, Materno-infantile, di Medicina Interna e Specialistica di Eccellenza “G. D’Alessandro”, PROMISEUniversità di PalermoPalermoItaly

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