Is vitamin D deficiency predictor of complications development in patients with HCV-related cirrhosis?
Around 130–170 million people in the world, according to WHO estimates, are infected with hepatitis C virus (HCV), with a wide variability in geographical distribution . HCV causes both acute and chronic hepatitis, the latter evolving to cirrhosis with impairment of liver structure and function, development of fibrosis, portal hypertension and hyperdinamic circulation . During this progression, the varying degree of fibrosis can be assessed through non-invasive serological tests and/or imaging techniques, which have been proposed as reliable indicators . Clinical complications of cirrhosis are esophageal varices, ascites with spontaneous bacterial peritonitis, hepato-renal syndrome, hepato-pulmunary syndrome and hepatic encephalopathy [4, 5].
Vitamin D is a secosteroid hormone which is involved in several processes . It has pleiotropic effects being mainly implicated in bone and calcium homeostasis, cardiovascular system function, pancreatic endocrine cells, muscle and...
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