Pathergy testing: prospective comparison of dermatoscopic evaluation and naked eye examination

  • Aysegul Sevim KeciciEmail author
  • Zekayi Kutlubay
  • Server Serdaroglu
  • Yalcin Tuzun
Part of the following topical collections:
  1. Behcet disease


Pathergy phenomenon is a non-specific tissue hyperreactivity reaction due to trauma and is a minor diagnostic criterion of Behcet's disease. In this study, 100 patients with a suspicion of Behcet's disease who were referred to Cerrahpasa Medical Faculty Dermatology department between 01.11.2014 and 31.01.2015 are included. Skin pathergy tests were applied to all the patients and results were evaluated by two dermatologists separately at 48th hour, each with naked eye and with dermatoscopy. Test results were scored on a scale of 0–6. At the end of the study, score results of naked eye and dermatoscopy for doctor number 1 were statistically similar. Same results applied for doctor number 2. However, naked eye results of doctor number 1 and 2 for the same patients were significantly different from each other (p 0.0372) and with dermatoscopy examination this difference was eliminated (p > 0.05). This study revealed that naked eye evaluation of pathergy test results can yield different results among different interpreters. Use of dermatoscopy during the evaluation process decreases interobserver variation and subjectivity of the test.


Pathergy test Pathergy phenomenon Behcet's disease Dermatoscopy 


Compliance with ethical standards

Conflict of interest

All the authors declare that they have no conflict of interest.

Statements on human and animal rights

This study was approved by the ethical committee of Cerrahpasa Medical Faculty.

Informed consent

Written informed consents of all patients were obtained before the study.


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Copyright information

© Società Italiana di Medicina Interna (SIMI) 2019

Authors and Affiliations

  1. 1.Department of DermatologyHaydarpasa Numune Training and Research Hospital, University of Medical SciencesIstanbulTurkey
  2. 2.Department of Dermatology, Cerrahpasa Medical FacultyIstanbul UniversityIstanbulTurkey
  3. 3.Department of DermatologyMedicalpark Bahcelievler Private HospitalIstanbulTurkey

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