Internal and Emergency Medicine

, Volume 13, Issue 8, pp 1181–1183 | Cite as

 Antithrombotic therapy and intracranial bleeding in subjects with sporadic brain arteriovenous malformations: preliminary results from a retrospective study

  • Cindy TiseoEmail author
  • Antonio Carolei

Brain arteriovenous malformations (AVMs) are anomalies of the vascular system of the brain, consisting of tangles of dilatated blood vessels, called the nidus, which connect the feeding arteries directly to the venous drainage without any interposed capillary bed. The exact pathogenic mechanism of AVMs formation is yet poorly understood, but it has been hypothesized that both genetic mutations and angiogenic stimulation play roles in their development. The vast majority of AVMs in the general population has a sporadic origin, but some lesions can occur as a part of hereditary syndromes, such as arteriovenous malformation syndrome and hereditary hemorrhagic telangiectasia, that result from mutations of genes involved in angiogenesis and vascular remodeling.

Despite the low estimated incidence (about 1.3 per 100,000 inhabitants per year) [1] and prevalence rates (10–18 per 100,000 persons) [1], and the low proportion of symptomatic patients (12%), AVMs pose a relevant neurological issue...


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Conflict of interest

The author(s) declare that they have no conflict of interest.

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This article does not contain any studies with human participants or animals performed by any of the authors.

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© Società Italiana di Medicina Interna 2018

Authors and Affiliations

  1. 1.Neurology and Stroke Unit, Department of Applied Clinical Sciences and Biotechnology, Avezzano HospitalUniversity of L’AquilaL’AquilaItaly

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