Progressive splenomegaly and mild thrombocytosis in beta-thalassaemia trait and coexisting hereditary hemochromatosis: possible confounders for a subsequent hematological diagnosis

  • Serena PelusiEmail author
  • Federica Iuculano
  • Rosa Lombardi
  • Paolo Francione
  • Umberto Gianelli
  • Anna Ludovica Fracanzani
  • Silvia Fargion

Case presentation

Dr. Iuculano, Dr. Pelusi, Dr. Lombardi, Dr. Francione

A 63-year-old woman regularly followed in our outpatient clinic and affected by hereditary hemochromatosis (HH), presented with sudden acute pain in the upper left abdominal quadrant.

The woman had been referred to our outpatient clinic several years before, at the age of 34, for the finding of elevated ferritin and circulating iron levels during hospitalization for acute hepatitis A. Elevation in iron parameters persisted even after hepatitis resolution.

Her previous medical history included a diagnosis of beta-thalassemia trait (hemoglobin levels 10–11 g/dl) and hysterectomy for menorrhagia at the age of 29. She had two full-term pregnancies, and had received iron therapy during those periods.

The family history was negative for hyperferritinemia. She reported 20 g ethanol consumption per day.

Her blood tests at first observation showed high levels in ferritin and transferrin saturation, lower end of normal...


Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Statement of human and animal rights

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. This article does not contain any studies with human and animals performed by any of the authors.

Informed consent

Informed consent by the patient was obtained by the authors.


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Copyright information

© Società Italiana di Medicina Interna 2018

Authors and Affiliations

  • Serena Pelusi
    • 1
    Email author
  • Federica Iuculano
    • 1
  • Rosa Lombardi
    • 1
  • Paolo Francione
    • 1
  • Umberto Gianelli
    • 2
  • Anna Ludovica Fracanzani
    • 1
  • Silvia Fargion
    • 1
  1. 1.Department of Pathophysiology and TransplantationUniversità degli Studi di Milano, Fondazione IRCCS Ca’ Granda Ospedale Maggiore PoliclinicoMilanItaly
  2. 2.Hematopathology Service, Pathology Unit, Department of Pathophysiology and TransplantationUniversità degli Studi di Milano, Fondazione IRCCS Ca’ Granda, Ospedale Maggiore PoliclinicoMilanItaly

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