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Internal and Emergency Medicine

, Volume 13, Issue 7, pp 1111–1119 | Cite as

Reliability of the CARE rule and the HEART score to rule out an acute coronary syndrome in non-traumatic chest pain patients

  • Thomas Moumneh
  • Vanessa Richard-Jourjon
  • Emilie Friou
  • Fabrice Prunier
  • Caroline Soulie-Chavignon
  • Jacques Choukroun
  • Betty Mazet-Guilaumé
  • Jérémie Riou
  • Andréa Penaloza
  • Pierre-Marie Roy
EM - ORIGINAL

Abstract

In patients consulting in the Emergency Department for chest pain, a HEART score ≤ 3 has been shown to rule out an acute coronary syndrome (ACS) with a low risk of major adverse cardiac event (MACE) occurrence. A negative CARE rule (≤ 1) that stands for the first four elements of the HEART score may have similar rule-out reliability without troponin assay requirement. We aim to prospectively assess the performance of the CARE rule and of the HEART score to predict MACE in a chest pain population. Prospective two-center non-interventional study. Patients admitted to the ED for non-traumatic chest pain were included, and followed-up at 6 weeks. The main study endpoint was the 6-week rate of MACE (myocardial infarction, coronary angioplasty, coronary bypass, and sudden unexplained death). 641 patients were included, of whom 9.5% presented a MACE at 6 weeks. The CARE rule was negative for 31.2% of patients, and none presented a MACE during follow-up [0, 95% confidence interval: (0.0–1.9)]. The HEART score was ≤ 3 for 63.0% of patients, and none presented a MACE during follow-up [0% (0.0–0.9)]. With an incidence below 2% in the negative group, the CARE rule seemed able to safely rule out a MACE without any biological test for one-third of patients with chest pain and the HEART score for another third with a single troponin assay.

Keywords

Chest pain Major adverse cardiac event Acute coronary syndrome Risk assessment 

Notes

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Statement of human and animal rights

 The study was approved by the Ethics Committee of the University Hospital Center of Angers on July 18th 2013, and registered N°2013/51. All procedures performed in this study were in accordance with the 1964 Helsinki declaration. This article does not contain any studies with animals performed by any of the authors.

Informed consent

Each patient’s consent was expressly sought and each participant was given a written information on the study. Signed consent forms were not required regarding French current laws on observational studies.

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Copyright information

© SIMI 2018

Authors and Affiliations

  • Thomas Moumneh
    • 1
  • Vanessa Richard-Jourjon
    • 2
  • Emilie Friou
    • 1
  • Fabrice Prunier
    • 3
  • Caroline Soulie-Chavignon
    • 1
  • Jacques Choukroun
    • 4
  • Betty Mazet-Guilaumé
    • 1
  • Jérémie Riou
    • 5
  • Andréa Penaloza
    • 6
  • Pierre-Marie Roy
    • 1
  1. 1.Institut MITOVASC, Département de Médecine d’UrgenceCHU d’Angers, Université d’AngersAngersFrance
  2. 2.Service de Médecine d’UrgenceCHU de PoitiersPoitiersFrance
  3. 3.Institut MITOVASC, Service de CardiologieCHU d’Angers, Université d’AngersAngersFrance
  4. 4.Service de Médecine d’UrgenceCH Le MansLe MansFrance
  5. 5.Unité de Formation-Recherche SantéUniversité d’Angers, MINT INSERM, UMR 6021AngersFrance
  6. 6.Service de Médecine d’UrgenceCliniques Universitaires St-LucBrusselsBelgium

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