Internal and Emergency Medicine

, Volume 12, Issue 2, pp 143–145 | Cite as

Cardiac biomarkers of acute coronary syndrome: from history to high-sensitive cardiac troponin

  • Mario PlebaniEmail author
  • Giorgia Antonelli
  • Martina Zaninotto

Acute coronary syndrome (CHD) represents a major cause of morbidity and mortality, accounting for more than 8 millions deaths in 2013 worldwide [1]. Nevertheless, the mortality associated with CHD has fallen steeply in the past few decades reflecting, at least in part, the shift in the pattern of acute coronary syndrome (ACS), with the rise in non-ST-segment elevation ACS (NSTE-ACS) and a decline in ST-segment elevation myocardial infarction (STEMI), the latter accounting for approximately one-third of all ACS events [2]. This shift in the last decade is basically due to a paradigmatic change in diagnostic testing with a widespread use of cardiac troponin assays, as well as to the change in the risk factor profile of patients with ACS [3]. Cardiac troponin [both troponin I (cTnI) and T (cTnT)] assay] has become globally recognized as the preferred biomarker for diagnosing ACS, replacing all other laboratory tests, including creatine kinase (CK), CK MB, and myoglobin for its “absolute”...


Acute Coronary Syndrome Acute Myocardial Infarction Acute Myocardial Infarction Cardiac Troponin Elevation Acute Coronary Syndrome 
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Conflict of interest

The authors declare that they have no conflict of interest.

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This article does not contain any studies with human participants or animals performed by any of the authors.

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© SIMI 2017

Authors and Affiliations

  1. 1.Department of Laboratory MedicineUniversity-HospitalPaduaItaly

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