Internal and Emergency Medicine

, Volume 13, Issue 1, pp 69–73 | Cite as

Cost effectiveness of pneumococcal urinary antigen in Emergency Department: a pragmatic real-life study

  • Aurélien DinhEmail author
  • Clara Duran
  • Benjamin Davido
  • Aurore Lagrange
  • Valérie Sivadon-Tardy
  • Frédérique Bouchand
  • Alain Beauchet
  • Jean-Louis Gaillard
  • Sébastien Beaune
  • Jérôme Salomon
  • Julie Grenet


Community-acquired pneumonia (CAP) is frequent and can be life-threatening. Streptococcus pneumoniae is the main bacteria involved, and is susceptible to penicillin A. Rapid microbiological diagnosis could then help reduce the antimicrobial spectrum. The pneumococcal urinary antigen (PUA) test is fast and easy to perform, but its impact on antimicrobial prescription and cost-effectiveness in emergency departments (ED) is not well known. We performed a pragmatic real life retrospective study in an adult ED to assess its usefulness: proportion of positive results, impact on antimicrobial prescriptions and cost-effectiveness. Over 3 years (from January 1st 2012 to December 31st 2014), 979 PUA tests were reutilized in our ED among 1224 patients who consulted for CAP; 51 (5.2%) were positive. Among them, 10 led to a modification of the antimicrobial treatment, but only 7 (14.3%) were in accordance with the results. The total cost of a PUA test is 27€. As only 7 PUA tests led to appropriate antimicrobial modification, we deemed that 972 had no impact, and the potential cost savings, if the test had not been used, would have been 26,244 € (972 × 27) during 3 years, that is 8748 € per year. Thus, it seems that the PUA test should not be generally used in the ED considering its low rate of positivity and the difficulties for physicians to adapt antibiotic treatment accordingly. This attitude change in utilization would lead to substantial cost savings.


Clinical management Cost effectiveness Infectious diseases Bacterial Community-acquired pneumonia 



Elodie Choisy.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.



Statement of human and animal rights

All procedures performed in studies involving human participants were in accordance with the ethical standards of the Ambroise Paré hospital institutional research committee and with the 1964 Helsinki declaration and its later amendments.

Informed consent

For this type of study, formal consent is not required.


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Copyright information

© SIMI 2016

Authors and Affiliations

  • Aurélien Dinh
    • 1
    Email author
  • Clara Duran
    • 1
  • Benjamin Davido
    • 1
  • Aurore Lagrange
    • 1
  • Valérie Sivadon-Tardy
    • 2
  • Frédérique Bouchand
    • 3
  • Alain Beauchet
    • 4
  • Jean-Louis Gaillard
    • 2
  • Sébastien Beaune
    • 5
  • Jérôme Salomon
    • 1
  • Julie Grenet
    • 5
  1. 1.Infectious Disease UnitUniversity Hospital Raymond Poincaré, AP-HP, Versailles Saint-Quentin UniversityGarchesFrance
  2. 2.Microbiology Laboratory, University Hospital Ambroise ParéAP-HP, Versailles Saint-Quentin UniversityBoulogne-BillancourtFrance
  3. 3.Pharmacy Department, University Hospital Raymond PoincaréAP-HP, Versailles Saint-Quentin UniversityGarchesFrance
  4. 4.IT Department, University Hospital Ambroise ParéAP-HP, Versailles Saint-Quentin UniversityBoulogne-BillancourtFrance
  5. 5.Emergency Department, University Hospital Ambroise ParéAP-HP, Versailles Saint-Quentin UniversityBoulogne-BillancourtFrance

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