Internal and Emergency Medicine

, Volume 13, Issue 1, pp 51–58 | Cite as

SOFA score and left ventricular systolic function as predictors of short-term outcome in patients with sepsis

  • Francesca InnocentiEmail author
  • Vittorio Palmieri
  • Aurelia Guzzo
  • Valerio Teodoro Stefanone
  • Chiara Donnini
  • Riccardo Pini


In a group of septic patients, we assess the short-term prognostic value of LV systolic performance, evaluated through conventional left ventricular ejection fraction (LVEF) and left ventricular global longitudinal strain (LV GLS). One hundred forty-seven patients with sepsis were recruited; LVEF by planimetry and peak GLS by 2D speckle tracking could be assessed within 24 h. The study population was stratified according to SOFA tertiles assessed at the time of the echocardiogram (G1: SOFA score <5; G2: SOFA score 5–7; G3: SOFA score >7). Day-7 follow-up data were used as reference. Patients in G2 and G3 show a significant hemodynamic derangement, paralleling the more pronounced organ damage by definition; nevertheless, LVEF and GLS are comparable among the three groups (both p > 0.1). All-cause mortality at day-7 follow-up is slightly lower in G1 (9%) versus G2 and G3 (14 and 26%, respectively, p = NS). Analyses through ROC curves focusing on day-7 mortality show that the SOFA score fairly correlates with events (AUC 0.635, p = 0.037), while low LVEF (AUC 0.35, p = 0.022) and less negative GLS (AUC 0.73, p = 0.001) do so. In multivariate analyses, mortality by day-7 follow-up is more likely per higher GLS (i.e., indicative of worst systolic dysfunction, HR 1.22/%, p = 0.005) and per increasing SOFA score (HR 1.22/unit, p = 0.010), whereas LVEF, adjusted for age and SOFA score, does not enter the prognostic model. In the very short term in patients with severe sepsis, LV systolic function assessment by means of GLS predicts the short-term prognosis, independent of SOFA.


Sepsis LV systolic function Prognostic scores 


Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Statement of human and animal rights

The study protocol was approved by the Toscana–Area vasta–Centro inter-institutional ethics committee (Registration Number OSS.13.031).

Informed consent

All patients signed an informed consent.


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Copyright information

© SIMI 2016

Authors and Affiliations

  1. 1.High-Dependency Unit, Department of Clinical and Experimental MedicineAzienda Ospedaliero-Universitaria CareggiFlorenceItaly
  2. 2.Cardiology Unit, Department of Heart and VesselsSG Moscati National HospitalAvellinoItaly

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