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Internal and Emergency Medicine

, Volume 10, Issue 3, pp 359–368 | Cite as

The Italian MacNew heart disease health-related quality of life questionnaire: a validation study

  • Francesco FattirolliEmail author
  • Niccolò Marchionni
  • Stefan Höfer
  • Pantaleo Giannuzzi
  • Elisabetta Angelino
  • Paolo Fioretti
  • Daniela Miani
  • Neil Oldridge
HTA-ORIGINAL

Abstract

Patient-centered treatment outcomes such as health-related quality of life are recommended in clinical care and research studies. Health-related quality of life questionnaires need to be validated in the language of the target population. The reliability and validity of the Italian version of the MacNew Questionnaire was determined in patients with angina, myocardial infarction, or ischemic heart failure. Sociodemographic and clinical data were collected on 298 patients [angina, n = 88; MI, n = 106; heart failure, n = 104; mean age, 64.8 (±10.6) years] at three centers in Italy. MacNew mean scores were higher (p < 0.001) in patients with myocardial infarction than in patients with either angina or heart failure with no floor and minimal ceiling effects. The three-factor structure of the original MacNew form was largely confirmed explaining 54.6 % of the total variance. The Italian MacNew version demonstrates high internal consistency reliability (Cronbach’s α ≥ 0.86), confirms the convergent validity hypotheses with strong correlations on six of eight comparisons (r ≥ 0.86), partially confirms discriminative validity with the SF-36 health transition item, and fully confirms discriminative validity with the Hospital Anxiety and Depression Scale. The Italian version of the MacNew Questionnaire demonstrates satisfactory psychometric properties, and is reliable and valid in Italian-speaking patients with angina, MI, or heart failure. Responsiveness could not be tested due to the cross-sectional design of the parent study, and needs to be investigated in an intervention study.

Keywords

Health-related quality of life Angina Myocardial infarction Heart failure Validity 

Notes

Acknowledgments

We thank all the patients who provided extensive personal information, and all those who recruited patients and collected data. The HeartQoL Project received partial funding from the European Society of Cardiology and the European Association of Cardiovascular Prevention and Rehabilitation.

Conflict of interest

None of the authors have a declared conflict of interest.

Ethical standard

The procedures followed were in accordance with the 1964 Declaration of Helsinki and its later amendments; the Ethics Committee at each of the study sites approved the project, and informed consent was obtained from all patients.

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Copyright information

© SIMI 2015

Authors and Affiliations

  • Francesco Fattirolli
    • 1
    Email author
  • Niccolò Marchionni
    • 1
  • Stefan Höfer
    • 2
  • Pantaleo Giannuzzi
    • 3
  • Elisabetta Angelino
    • 3
  • Paolo Fioretti
    • 4
  • Daniela Miani
    • 4
  • Neil Oldridge
    • 5
  1. 1.Department of Experimental and Clinical MedicineUniversity of Florence and Azienda Ospedaliero Universitaria CareggiFlorenceItaly
  2. 2.Department of Medical PsychologyInnsbruck Medical UniversityInnsbruckAustria
  3. 3.Salvatore Maugeri FoundationIRCCS, Scientific Institutes of Torino and VerunoVerunoItaly
  4. 4.Azienda Ospedaliero Universitaria S. Maria della Misericordia and IRCAB FoundationUdineItaly
  5. 5.College of Health SciencesUniversity of Wisconsin-MilwaukeeWisconsinUSA

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