Internal and Emergency Medicine

, Volume 10, Issue 3, pp 321–328 | Cite as

Fecal calprotectin and ulcerative colitis endoscopic activity index as indicators of mucosal healing in ulcerative colitis

  • Tarang Taghvaei
  • Iradj Maleki
  • Farshad Nagshvar
  • Hafez Fakheri
  • Vahid Hosseini
  • Seyed Mohammad Valizadeh
  • Hassan Neishaboori


Ulcerative colitis (UC) is a chronic, idiopathic, inflammatory large bowel disease with recurrent variable periods of exacerbation. The aim of the current study is to evaluate the correlation of UCEIS with fecal calprotectin (FC) level to assess disease activity in UC patients in order to determine whether FC can prognosticate clinical outcome and disease activity of UC instead of colonoscopic evaluation. Our endoscopic investigations revealed the extension of UC as the following: proctitis (11.6 %), procto-sigmoiditis (18.5 %), left-sided colitis (15.8 %), extensive colitis (11.7 %), and normal endoscopy (42.4 %). Conclusively, we suggest that FC can be used as a reliable tool to evaluate disease activity in ulcerative colitis patients. Moreover, our findings indicate a significant correlation between FC level and mucosal healing.


Calprotectin UCEIS Mucosal healing Ulcerative colitis Inflammatory bowel disease 


Conflict of interest



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Copyright information

© SIMI 2014

Authors and Affiliations

  • Tarang Taghvaei
    • 1
  • Iradj Maleki
    • 1
  • Farshad Nagshvar
    • 2
  • Hafez Fakheri
    • 1
  • Vahid Hosseini
    • 1
  • Seyed Mohammad Valizadeh
    • 1
  • Hassan Neishaboori
    • 1
  1. 1.Inflammatory Diseases of Upper Gastrointestinal Tract Research CenterImam Khomeini Hospital, Mazandaran University of Medical SciencesSariIran
  2. 2.Department of PathologyMazandaran University of Medical SciencesSariIran

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