Internal and Emergency Medicine

, Volume 7, Issue 2, pp 181–182 | Cite as

Colchicine is safe and effective for secondary prevention of recurrent pericarditis

  • Francesca Gianni
  • Monica SolbiatiEmail author
  • Gruppo di Autoformazione Metodologica (GrAM)


Recurrence is the most common complication of acute pericarditis, occurring in 10–30 % of patients with a first episode, and again in up to 50 % after a first recurrence of acute pericarditis [1].

Observational studies [2, 3, 4] and an open-label, single-center, randomized trial [5] show that colchicine can significantly reduce pericarditis recurrence rate. On the basis of these data, colchicine is recommended in the European Society of Cardiology guidelines (level of evidence B, class IIa indication) for the initial attack as well as the prevention of recurrences of acute pericarditis [6].

However, no multicenter, double-blind, randomized trial has confirmed these favorable findings.


The CORP (COlchicine for Recurrent Pericarditis) trial [7] is a prospective, randomized, double-blind, placebo-controlled, multicenter trial to evaluate the efficacy and safety of colchicine (1.0–2.0 mg on the first day, followed by a maintenance dose of 0.5–1.0 mg/day for 6 months) in...


Colchicine Pericarditis Relative Risk Reduction Cardiac Tamponade Absolute Risk Reduction 
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Conflict of interest



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Copyright information

© SIMI 2012

Authors and Affiliations

  • Francesca Gianni
    • 1
  • Monica Solbiati
    • 1
    Email author
  • Gruppo di Autoformazione Metodologica (GrAM)
  1. 1.Medicina Interna II, Azienda Ospedaliera L. Sacco, Università degli Studi di MilanoMilanItaly

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