Internal and Emergency Medicine

, Volume 8, Issue 8, pp 695–702 | Cite as

Differential diagnosis of pulmonary embolism in outpatients with non-specific cardiopulmonary symptoms

  • Alessandro Squizzato
  • Davide Luciani
  • Andrea Rubboli
  • Leonardo Di Gennaro
  • Raffaele Landolfi
  • Carlo De Luca
  • Fernando Porro
  • Marco Moia
  • Sophie Testa
  • Davide Imberti
  • Guido Bertolini
IM - ORIGINAL

Abstract

Most cardiopulmonary diseases share at least one symptom with pulmonary embolism (PE). The aim of this study was to identify the most common acute causes of dyspnea, chest pain, fainting or palpitations, which diagnostic procedures were performed and whether clinicians investigate them appropriately. An Italian multicenter collaboration gathered 17,497 Emergency Department (ED) records of patients admitted from January 2007 to June 2007 in six hospitals. A block random sampling procedure was applied to select 800 hospitalised patients. Results of the overall 17,497 patients were obtained by weighting sampled cases according to the probability of the randomisation block variables in the whole population. The case-mix of enrolled patients was assessed in terms of cardiopulmonary symptoms, and the prevalence of acute disorders. The actual performance of procedures was compared with a measure of their accuracy as expected in the most common clinical presentations. PE occurred in less than 4% of patients with cardiopulmonary symptoms. Acute heart failure, pneumonia and chronic obstructive pulmonary disease exacerbation were the most likely diagnoses in patients with dyspnea. Acute myocardial infarction was present in roughly 10% of patients with chest pain. Atrial fibrillation was the prevalent diagnosis in patients with palpitations. Echocardiography, computed tomographic pulmonary angiography, perfusion lung scan, D-dimer test and B-type natriuretic peptide were performed less than expected from their accuracy. Diagnostic strategies, starting from non-specific symptoms and coping with the eventuality of PE, are likely to benefit from an increased awareness of the examination’s accuracy in discriminating among several competing hypotheses, rather than in testing the single PE suspicion.

Keywords

Pulmonary embolism Differential diagnosis 

Notes

Acknowledgments

We are indebted to Simon Vittorio Mark Braham, Giorgi Pierfranceschi Matteo, Francesca Paganelli, Giovanni Giannelli, and Giuseppe Pigoli for both data collection and critical revision of final diagnoses. Sanofi-Aventis financially supported data collection

Conflict of interest

None

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Copyright information

© SIMI 2011

Authors and Affiliations

  • Alessandro Squizzato
    • 1
    • 9
  • Davide Luciani
    • 2
  • Andrea Rubboli
    • 3
  • Leonardo Di Gennaro
    • 4
  • Raffaele Landolfi
    • 4
  • Carlo De Luca
    • 5
  • Fernando Porro
    • 6
  • Marco Moia
    • 6
  • Sophie Testa
    • 7
  • Davide Imberti
    • 8
  • Guido Bertolini
    • 2
  1. 1.Department of Clinical Medicine, Research Center on Thromboembolic Disorders and Antithrombotic TherapiesUniversity of InsubriaVareseItaly
  2. 2.‘Mario Negri’ Institute for Pharmacological ResearchMilanItaly
  3. 3.Department of CardiologyOspedale MaggioreBolognaItaly
  4. 4.Haemostasis Research CenterCatholic UniversityRomeItaly
  5. 5.Department of RadiologyPoliclinico Sant′OrsolaMalpighiItaly
  6. 6.Ospedale Maggiore PoliclinicoMilanItaly
  7. 7.Thrombosis and Haemostasis CenterIstituti Ospitalieri di CremonaCremonaItaly
  8. 8.Department of Internal MedicinePiacenzaItaly
  9. 9.U.O. Medicina I, Ospedale di CircoloVareseItaly

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