Internal and Emergency Medicine

, Volume 6, Issue 1, pp 23–28 | Cite as

Rehabilitating chronic migraine complicated by medication overuse headaches: how can we prevent migraine relapse?

  • Ivano Farinelli
  • Ilaria Dionisi
  • Paolo Martelletti
IM - Review

Abstract

Headache is among the most common neurological symptoms in clinical practice. In some cases of episodic migraine, the headache intensifies into a chronic form, defined as chronic migraine (CM) and such a condition encompasses a headache frequency of 15 days/month, with features similar to those of migraine attacks. The assessment of CM in the US general population ranges around 1.3–2%. Migraine progression from an episodic into a chronic form is realized through a period of time involving several months or years, during which an increase attack frequency occurs. Both Topiramate and Onabotulinum toxin A can be considered to be safe as well as effective medications, therefore, representing a treatment choice. Regarding drug abusers, the initial relief step always consists of drug interruption. Only after detoxification can a new prophylaxis therapy be commenced, which otherwise would be useless from the start. The feasible diagnostic setting for the tailored treatment of CM based on the application of pharmacogenomics will allow us in predetermining the efficacy of a single old and new drugs by avoiding abuse due to non-responsivity of the abused drug.

Keywords

Chronic migraine Medication overuse headache Detoxification Reprophylaxis 

References

  1. 1.
    Headache Classification Committee of the International Headache Society (2004) Classification and diagnostic criteria for headache disorders, cranial neuralgias and facial pain, 2nd edn. Cephalalgia 24:1–160Google Scholar
  2. 2.
    Scher AI, Stewart WF, Liberman J, Lipton RB (1998) Prevalence of frequent headache in a population sample. Headache 38:497–506PubMedCrossRefGoogle Scholar
  3. 3.
    Headache Classification Committee, Olesen J, Bousser MG, Diener HC et al (2006) New appendix criteria open for a broader concept of chronic migraine. Cephalalgia 26:742–746PubMedCrossRefGoogle Scholar
  4. 4.
    Stovner LJ, Zwart JA, Hagen K, Terwindt GM, Pascual J (2006) Epidemiology of headache in Europe. Eur J Neurol 13:333–345PubMedCrossRefGoogle Scholar
  5. 5.
    Castillo J, Muñoz P, Guitera V, Pascual J (1999) Kaplan award 1998: epidemiology of chronic daily headache in the general population. Headache 39:190–196PubMedCrossRefGoogle Scholar
  6. 6.
    Bigal ME, Lipton RB (2008) Concepts and mechanisms of migraine chronification. Headache 48:7–15PubMedCrossRefGoogle Scholar
  7. 7.
    Harris JA, Corsi M, Quartaroli M, Arban R, Bentivoglio M (1996) Upregulation of spinal glutamate receptors in chronic pain. Neuroscience 74:7–12PubMedCrossRefGoogle Scholar
  8. 8.
    Coderre TJ, Yashpal K (1994) Intracellular messengers contributing to persistent nociception and hyperalgesia induced by l-glutamate and substance P in the rat formalin pain model. Eur J Neurosci 6:1328–1334PubMedCrossRefGoogle Scholar
  9. 9.
    Herrero JF, Laird JM, López-García JA (2000) Wind-up of spinal cord neurones and pain sensation: much ado about something? Prog Neurobiol 61:169–203PubMedCrossRefGoogle Scholar
  10. 10.
    Gallai V, Alberti A, Gallai B, Coppola F, Floridi A, Sarchielli P (2003) Glutamate and nitric oxide pathway in chronic daily headache: evidence from cerebrospinal fluid. Cephalalgia 23:166–174PubMedCrossRefGoogle Scholar
  11. 11.
    Mitsikostas DD, Sanchez del Rio M (2001) Receptor systems mediating c-fos expression within trigeminal nucleus caudalis in animal models of migraine. Brain Res Brain Res Rev 35:20–35PubMedCrossRefGoogle Scholar
  12. 12.
    Welch KM, Nagesh V, Aurora SK, Gelman N (2001) Periaqueductal gray matter dysfunction in migraine: cause or the burden of illness? Headache 41:629–637PubMedCrossRefGoogle Scholar
  13. 13.
    Scher AI, Midgette LA, Lipton RB (2008) Risk factors for headache chronification. Headache 48:16–25PubMedCrossRefGoogle Scholar
  14. 14.
    Katsarava Z, Schneeweiss S, Kurth T et al (2004) Incidence and predictors for chronicity of headache in patients with episodic migraine. Neurology 62:788–790PubMedGoogle Scholar
  15. 15.
    Silberstein S, Olesen J, Bousser MG et al (2005) The International Classification of Headache Disorders, 2nd edition (ICHD-II)—-revised of criteria for 8.2 medication-overuse headache. Cephalalgia 25:460–465PubMedCrossRefGoogle Scholar
  16. 16.
    Diener HC, Limmroth V (2004) Medication-overuse headache: a worldwide problem. Lancet Neurol 3:475–483PubMedCrossRefGoogle Scholar
  17. 17.
    Paemeleire K, Crevits L, Goadsby PJ, Kaube H (2006) Practical management of medication-overuse headache. Acta Neurol Belg 106:43–51PubMedGoogle Scholar
  18. 18.
    Obermann M, Katsarava Z (2007) Management of medication-overuse headache. Expert Rev Neurother 7:1145–1155PubMedCrossRefGoogle Scholar
  19. 19.
    Pageler L, Katsarava Z, Diener HC, Limmroth V (2008) Prednisone versus placebo in withdrawal therapy following medication overuse headache. Cephalalgia 28:152–156PubMedGoogle Scholar
  20. 20.
    Krymchantowski AV, Barbosa JS (2000) Prednisone as initial treatment of analgesic-induced daily headache. Cephalalgia 20:107–113PubMedCrossRefGoogle Scholar
  21. 21.
    Katsarava Z, Muessig M, Dzagnidze A, Fritsche G, Diener HC, Limmroth V (2005) Medication overuse headache: rates and predictors for relapse in a 4-year prospective study. Cephalalgia 25:12–15PubMedCrossRefGoogle Scholar
  22. 22.
    Simpson LL (1980) Kinetic studies on the interaction between botulinum toxin type A and the cholinergic neuromuscular junction. J Pharmacol Exp Ther 213:504–508PubMedGoogle Scholar
  23. 23.
    Aoki KR (2003) Evidence for antinociceptive activity of botulinum toxin type A in pain management. Headache 43:S9–S15PubMedCrossRefGoogle Scholar
  24. 24.
    Durham PL, Cady R, Cady R (2004) Regulation of calcitonin gene-related peptide secretion from trigeminal nerve cells by botulinum toxin type A: implications for migraine therapy. Headache 44:35–43PubMedCrossRefGoogle Scholar
  25. 25.
    Dodick DW, Mauskop A, Elkind AH et al (2005) Botulinum toxin type A for the prophylaxis of chronic daily headache: subgroup analysis of patients not receiving other prophylactic medications: a randomized double-blind, placebo-controlled study. Headache 45:315–324PubMedCrossRefGoogle Scholar
  26. 26.
    Mathew NT, Frishberg BM, Gawel M et al (2005) Botulinum toxin type A (BOTOX) for the prophylactic treatment of chronic daily headache: a randomized, double-blind, placebo-controlled trial. Headache 45:293–307PubMedCrossRefGoogle Scholar
  27. 27.
    Farinelli I, Coloprisco G, De Filippis S, Martelletti P (2006) Long-term benefits of botulinum toxin type A (Botox) in chronic daily headache: a five-year long experience. J Headache Pain 7:407–412PubMedCrossRefGoogle Scholar
  28. 28.
    Silberstein SD, Blumenfeld AM, Cady RK (2009) Onabotulinum toxin A for treatment of chronic migraine: analysis of the PREEMPT chronic migraine subgroup who were overusing acute headache medication at baseline. IHS 14th Congress. Cephalalgia P049:31Google Scholar
  29. 29.
    Akerman S, Goadsby PJ (2005) Topiramate inhibits cortical spreading depression in rat and cat: impact in migraine aura. Neuroreport 16:1383–1387PubMedCrossRefGoogle Scholar
  30. 30.
    Storer RJ, Goadsby PJ (2004) Topiramate inhibits trigeminovascular neurons in the cat. Cephalalgia 24:1049–1056PubMedCrossRefGoogle Scholar
  31. 31.
    Silberstein SD, Neto W, Schmitt J, Jacobs D et al (2004) Topiramate in migraine prevention: results of a large controlled trial. Arch Neurol 61:490–495PubMedCrossRefGoogle Scholar
  32. 32.
    Peres MF, Mercante JP, Tanuri FC, Nunes M, Zukerman E (2006) Chronic migraine prevention with topiramate. J Headache Pain 7:185–187PubMedCrossRefGoogle Scholar
  33. 33.
    Mosek A, Dano M (2005) Topiramate in the treatment of refractory chronic daily headache: an open trial. J Headache Pain 6:77–80PubMedCrossRefGoogle Scholar
  34. 34.
    Diener HC, Bussone G, Van Oene JC et al (2007) Topiramate reduces headache days in chronic migraine: a randomized, double-blind, placebo-controlled study. Cephalalgia 27:814–823PubMedCrossRefGoogle Scholar
  35. 35.
    Silberstein SD, Lipton RB, Dodick DW et al (2007) Efficacy and safety of topiramate for the treatment of chronic migraine: a randomized, double-blind, placebo-controlled trial. Headache 47:170–180PubMedCrossRefGoogle Scholar
  36. 36.
    Láinez MJ, Freitag FG, Pfeil J, Ascher S, Olson WH, Schwalen S (2007) Time course of adverse events most commonly associated with topiramate for migraine prevention. Eur J Neurol 14:900–906PubMedCrossRefGoogle Scholar
  37. 37.
    Ruiz L, Ferrandi D (2009) Topiramate in migraine progression. J Headache Pain 10:419–422PubMedCrossRefGoogle Scholar
  38. 38.
    Mathew NT, Jaffri SF (2009) A double-blind comparison of onabotulinumtoxin (BOTOX) and topiramate (TOPAMAX) for the prophylactic treatment of chronic migraine: a pilot study. Headache 49:1466–1478PubMedCrossRefGoogle Scholar
  39. 39.
    Rossi P, Jensen R, Nappi G et al (2009) A narrative review on the management of medication overuse headache: the steep road from experience to evidence. J Headache Pain 10:407–417PubMedCrossRefGoogle Scholar
  40. 40.
    Gentile G, Missori S, Borro M, Sebastianelli A, Simmaco M, Martelletti P (2010) Frequencies of genetic polymorphisms related to triptans metabolism in chronic migraine. J Headache Pain. doi 10.1007/s10194-010-0202-7
  41. 41.
    Di Lorenzo C, Di Lorenzo G, Sances G et al (2009) Drug consumption in medication overuse headache is influenced by brain-derived neurotrophic factor Val66Met polymorphism. J Headache Pain 10:349–355PubMedCrossRefGoogle Scholar
  42. 42.
    Stovner LJ, Tronvik E, Hagen K (2009) New drugs for migraine. J Headache Pain 10:395–406PubMedCrossRefGoogle Scholar
  43. 43.
    Farinelli I, De Filippis S, Coloprisco G, Missori S, Martelletti P (2009) Future drugs for migraine. Int Emerg Med 4:367–373CrossRefGoogle Scholar
  44. 44.
    Simmaco M, Borro M, Missori S, Martelletti P (2009) Pharmacogenomics in migraine: catching biomarkers for a predictable disease control. Exp Rev Neurother 9:1267–1269CrossRefGoogle Scholar

Copyright information

© SIMI 2010

Authors and Affiliations

  • Ivano Farinelli
    • 1
    • 2
  • Ilaria Dionisi
    • 2
  • Paolo Martelletti
    • 1
  1. 1.Department of Medical and Molecular Sciences, II School of Medicine, Sant’Andrea HospitalSapienza University of RomaRomeItaly
  2. 2.Department of Anaesthesia and Intensive Care Medicine, II School of Medicine, Sant’Andrea HospitalSapienza University of RomeRomeItaly

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