Internal and Emergency Medicine

, Volume 4, Issue 1, pp 75–77

Budd-Chiari syndrome in a paroxysmal nocturnal hemoglobinuria patient with previous cerebral venous thrombosis

  • Antonella Tufano
  • Nicola Macarone Palmieri
  • Ernesto Cimino
  • Fiorella Alfinito
  • Anna Maria Cerbone
CE - Letter to the Editor


  1. 1.
    Parker C, Omine M, Richards S et al (2005) Diagnosis and management of paroxysmal nocturnal hemoglobinuria. Blood 106:3699–3709PubMedCrossRefGoogle Scholar
  2. 2.
    Hill A, Hillmen P, Richards SJ, Elebute D, Marsh JC, Chan J, Mojcik CF, Rother RP (2005) Sustained response and long-term safety of eculizumab in paroxysmal nocturnal hemoglobinuria. Blood 106:2559–2565PubMedCrossRefGoogle Scholar
  3. 3.
    Brodsky RA (2008) Advances in the diagnosis and therapy of paroxysmal nocturnal hemoglobinuria. Blood Rev 22:65–74PubMedCrossRefGoogle Scholar
  4. 4.
    Vergniol J, Laharie D, Drouillard J et al (2005) Paroxysmal nocturnal hemoglobinuria and Budd-Chiari syndrome: therapeutic challenge with bone marrow transplantation, transjugular intrahepatic portosystemic shunt, and vena cava stent. Eur J Gastroenterol Hepatol 17(4):453–456PubMedCrossRefGoogle Scholar
  5. 5.
    Valla D, Dhumeaux D, Babany G et al (1987) Hepatic vein thrombosis in paroxysmal nocturnal hemoglobinuria A spectrum from asymptomatic occlusion of hepatic venules to fatal Budd-Chiari syndrome. Gastroenterology 93:569–575PubMedGoogle Scholar
  6. 6.
    Hall C, Richards S, Hillmen P (2003) Primary prophylaxis with warfarin prevents thrombosis in paroxysmal nocturnal hemoglobinuria (PNH). Blood 102:3587–3591PubMedCrossRefGoogle Scholar
  7. 7.
    Hillmen P, Lewis SM, Bessler M, Luzzatto L, Dacie JV (1995) Natural history of paroxysmal nocturnal hemoglobinuria. N Engl J Med 333:1253–1258PubMedCrossRefGoogle Scholar
  8. 8.
    Ziakas PD, Poulou LS, Rokas GI, Bartzoudis D, Voulgarelis M (2007) Thrombosis in paroxysmal nocturnal hemoglobinuria: sites, risks, outcome. An overview. J Thromb Haemost 5:642–645PubMedCrossRefGoogle Scholar
  9. 9.
    Shamseddine AI, Otrock ZK, Mahfouz RA et al (2005) Budd-Chiari sindrome in a paroxysmal nocturnal hemoglobinuria patient with coexistence of factor II and MTHFR mutations. J Thromb Haemost 3:1111PubMedCrossRefGoogle Scholar
  10. 10.
    Alfinito F, Del Vecchio L, Rocco S, Boccuni P, Musto P, Rotoli B (1996) Blood cell flow cytometry in paroxysmal nocturnal hemoglobinuria: a tool for measuring the extent of the PNH clone. Leukemia 10:1326–1330PubMedGoogle Scholar
  11. 11.
    Sharma A, Itha S, Baijal SS, Gupta R, Sonkar A, Aggarwal R (2005) Superior sagittal sinus thrombosis and Budd-Chiari syndrome due to paroxysmal nocturnal hemoglobinuria managed with transjugular intrahepatic portosystemic shunt: a case report. Trop Gastroenterol 26:146–148PubMedGoogle Scholar

Copyright information

© SIMI 2008

Authors and Affiliations

  • Antonella Tufano
    • 1
  • Nicola Macarone Palmieri
    • 1
  • Ernesto Cimino
    • 1
  • Fiorella Alfinito
    • 2
  • Anna Maria Cerbone
    • 1
  1. 1.Regional Reference Centre for Coagulation Disorders, Department of Clinical and Experimental MedicineFederico II University of NaplesNaplesItaly
  2. 2.Division of HematologyFederico II University of NaplesNaplesItaly

Personalised recommendations