Internal and Emergency Medicine

, Volume 3, Issue 1, pp 9–16

Troponin I in the intensive care unit setting: from the heart to the heart

  • Chiara Lazzeri
  • Manuela Bonizzoli
  • Giovanni Cianchi
  • Gian Franco Gensini
  • Adriano Peris
IM - Review

DOI: 10.1007/s11739-008-0089-3

Cite this article as:
Lazzeri, C., Bonizzoli, M., Cianchi, G. et al. Intern Emerg Med (2008) 3: 9. doi:10.1007/s11739-008-0089-3

Abstract

When measured in the plasma, cardiac troponins T (cTnT) and I (cTnI) are considered to be highly specific markers of myocardial cell damage; however, research has demonstrated that troponin elevation may associated with causes other than coronary artery disease. In the intensive care unit (ICU) setting, increased cTnI levels are quite common findings and when documented, even on admission, intensivists should bear in mind that this laboratory finding holds a prognostic role independent of the reason for ICU admission. The mechanism(s) (such as demand ischemia, myocardial strain, etc.) and not simply the cause (i.e., renal failure) of the increment in serum cTnI should be investigated to better tailor the therapeutical regimen in the single patient. In this review, we therefore consider the nonthrombotic causes of troponin elevation in the critical setting.

Keywords

Troponin Critically ill Intensive care unit Trauma Sepsis 

Copyright information

© SIMI 2008

Authors and Affiliations

  • Chiara Lazzeri
    • 1
  • Manuela Bonizzoli
    • 2
  • Giovanni Cianchi
    • 2
  • Gian Franco Gensini
    • 1
  • Adriano Peris
    • 2
    • 3
  1. 1.Intensive Cardiac Care Unit, Heart and Vessel Department, Azienda Ospedaliero-Universitaria CareggiUniversity of FlorenceFlorenceItaly
  2. 2.Intensive Care Unit, Emergency DepartmentAzienda Ospedaliero-Universitaria CareggiFlorenceItaly
  3. 3.FlorenceItaly

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