Acupuncture with Du’s heat-reinforcing method for diarrhea-predominant irritable bowel syndrome: a randomized controlled trial

  • Xue Zhang (张雪)
  • Min Ding (丁敏)Email author
  • Hua Feng (冯骅)
Clinical Study



To compare the clinical efficacy of Du’s heat-reinforcing method and Western medication in treating diarrhea-predominant irritable bowel syndrome (IBS-D).


Sixty-five IBS-D patients were randomized into two groups by the random number table. Thirty-three cases in the treatment group were intervened by acupuncture with Du’s heat-reinforcing method, while thirty-two cases in the control group were given oral administration of pinaverium bromide tablets. The intervention lasted 4 weeks for both groups. The IBS symptom severity score (IBS-SSS), IBS-quality of life (IBS-QOL) and hospital anxiety and depression scale (HAD) were adopted to evaluate the therapeutic efficacy.


The two groups each had two dropout cases. The clinical recovery rate was 38.7% and the total effective rate was 90.3% in the treatment group versus 13.3% and 66.7% in the control group. The treatment group was superior to the control group in both clinical recovery rate and total effective rate (both P<0.05). After 1-week and 4-week treatment, respectively, the IBS-SSS scores were lower compared with the baseline in both groups, and the intra-group differences were statistically significant (all P<0.05); the score in the treatment group was lower than that in the control group, and the between-group difference was statistically significant (both P<0.05). After 4-week treatment, the component scores of IBS-QOL showed improvements in both groups, and the treatment group was superior to the control group in the improvements of dysphoria, interference with activity, health worry and food avoidance (all P<0.05). The anxiety and depression scales of HAD (HAD-a, HAD-d) in the treatment group and the HAD-a in the control group obtained significant improvements (all P<0.05); the scores of HAD-a and HAD-d in the treatment group were significantly better than those in the control group (both P<0.05).


Acupuncture with Du’s heat-reinforcing method can effectively ease the symptoms of IBS-D, improve the quality of life and the state of anxiety and depression. It can produce a more significant efficacy than oral administration of pinaverium bromide tablets.


Acupuncture Therapy Acupuncture Reinforcing Method Irritable Bowel Syndrome Diarrhea Randomized Controlled Trial Du Xiao-shan 

“杜氏热补法” 针刺治疗腹泻型肠易激综合征: 随机对照研究



比较 “杜氏热补法” 与西药治疗腹泻型肠易激综合征(IBS-D)的临床疗效。


将65例IBS-D患者按随机数字表法随机分为2组, 治疗组33例采用 “杜氏热补法” 针刺治疗, 对照组32例口服匹维溴铵片治疗。 两组均治疗4周。 通过肠易激综合征症状严重度评分(IBS-SSS)、 肠易激综合征生活质量评分(IBS-QOL)、 医院焦虑抑郁量表(HAD)评定两组疗效。


治疗组脱落2例, 对照组脱落2例。 治疗组临床治愈率38.7%, 总有效率90.3%; 对照组临床治愈率13.3%, 总有效率66.7%。 治疗组的临床治愈率及总有效率均优于对照组(均P<0.05)。 治疗1周和4周后, 两组IBS-SSS评分均低于治疗前, 组内差异具有统计学意义(均P<0.05); 治疗组评分低于对照组, 组间差异具有统计学意义(均P<0.05)。 治疗4周后, 两组IBS-QOL各项评分均改善, 治疗组在改善烦躁不安、 冲突行为、 健康忧虑、 饮食限制方面优于对照组(均P<0.05); 治疗组HAD中焦虑子量表(HAD-a)和抑郁子量表(HAD-d), 以及对照组的HAD-a评分均有改善(均P<0.05); 治疗组HAD-a和HAD-d评分均优于对照组(均P<0.05)。


“杜氏热补法” 针刺可有效缓解IBS-D患者临床症状, 提高患者生活质量, 改善患者焦虑、 抑郁状态, 疗效优于口服匹维溴铵片。


针刺疗法 针刺补法 肠易激综合征 腹泻 随机对照试验 杜晓山 





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This work was supported by Jiangsu Planned Project for Fostering Talents in Six Scientific Fields (江苏省六大人才高峰项目, No. 2014-WSN-067); Project of Jiangsu Provincial Department of Science and Technology (江苏省科技厅项目, No. BL2014100); Medical Innovative Teambuilding Project of Wuxi Municipal Commission of Health and Family Planning (无锡市卫计委医学创新团队建设项 目, No. CXTDJS006); Scientific Research Project of Wuxi Hospital Management Center (无锡市医院管理中心科研项目, No. YGZXZ1525); Project of Wuxi Hospital of Traditional Chinese Medicine (无锡市中医医院项目, No. 20170004).


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Copyright information

© Shanghai Research Institute of Acupuncture and Meridian 2019

Authors and Affiliations

  • Xue Zhang (张雪)
    • 1
  • Min Ding (丁敏)
    • 1
    Email author
  • Hua Feng (冯骅)
    • 1
  1. 1.Acupuncture-moxibustion DepartmentWuxi Hospital of Traditional Chinese MedicineJiangsu Province, WuxiChina

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