Therapeutic effect observation on acupuncture plus medication for post-stroke depression

  • Da-rui Zhang (张大锐)Email author
  • Xin Peng (彭新)
  • Yong Zhi (智勇)
Clinical Study



To observe the clinical efficacy of acupuncture with medication for post-stroke depression.


A total of 96 patients with post-stroke depression were randomized into an observation group and a control group, with 48 cases in each group. The control group was treated with oral fluoxetine hydrochloride capsules, and the observation group was treated with acupuncture on the basis of the treatment of the control group. After 6 months of treatment, the traditional Chinese medicine (TCM) symptom scores, and Hamilton depression scale (HAMD) component scores and total scores of the two groups before and after treatment were observed, and the clinical efficacy and adverse reaction rate were compared between the two groups.


The total effective rate was 95.8% in the observation group and 83.3% in the control group, and the difference between the two groups was statistically significant (P<0.05). After treatment, the intra-group differences in TCM symptom scores and HAMD score of both groups were statistically significant (all P<0.01). In the observation group, the scores of indifferent expression, emotional restlessness, and sentimentality in the TCM symtoms were statistically different from those in the control group (all P<0.01). The scores of desperate factor and sleep disorder factor and total score in HAMD in the observation group were significantly different from those in the control group (all P<0.01). The incidence of adverse reactions was 6.3% in the observation group and 4.2% in the control group, and the difference was not significant between the two groups (P>0.05).


Acupuncture plus medication is an effective method for post-stroke depression, and it can further improve the patient's bad mood.


Acupuncture Therapy Stroke Complications Depression Emotions Acupuncture Medication Combined Points,Head &Neck 






将96例卒中后抑郁患者随机分为治疗组和对照组, 每组48例。 对照组采用口服盐酸氟西汀胶囊治疗, 治疗组在对照组基础上采用针刺治疗。 治疗6个月后, 观察两组治疗前后各项中医证候评分、 汉密尔顿抑郁量表(HAMD)各因子评分及总分的变化情况, 并比较两组临床疗效及不良反应发生率。


治疗组总有效率为95.8%, 对照组为83.3%, 两组比较差异具有统计学意义 (P<0.05)。 两组治疗后各项中医证候评分、 HAMD各因子评分及总分与同组治疗前比较, 差异均具有统计学意义 (均P<0.01)。 治疗组治疗后中医证候中表情冷漠、 情绪不宁、 多愁善感评分与对照组差异具有统计学意义(均 P<0.01)。 治疗组治疗后HAMD中绝望因子、 睡眠障碍因子评分及总分与对照组差异具有统计学意义(均P<0.01)。 治疗组不良反应发生率为6.3%, 对照组为4.2%, 两组比较差异无统计学意义(P>0.05)。


针刺配合药物是一种治疗卒中后抑郁的有效方法, 能进一步改善患者不良情绪。


针刺疗法 中风 并发症 抑郁 情绪 针药并用 穴位, 头颈部 





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This work was supported by Natural Science Foundation of Xinjiang Uygur Autonomous Region (新疆维吾尔自治区自然科学基金项目, No. 2018D01C163).


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Copyright information

© Shanghai Research Institute of Acupuncture and Meridian 2019

Authors and Affiliations

  • Da-rui Zhang (张大锐)
    • 1
    Email author
  • Xin Peng (彭新)
    • 1
  • Yong Zhi (智勇)
    • 2
  1. 1.Urumqi Chinese Medicine HospitalXinjiang Uygur Autonomous RegionUrumqiChina
  2. 2.Traditional Chinese Medical CollegeXinjiang Medical UniversityUrumqiChina

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