Côlon & Rectum

, Volume 5, Issue 4, pp 239–245 | Cite as

Slow-transit constipation: evidence-based treatments

Dossier Thématique / Thematic File Constipation
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Abstract

Slow-transit constipation is a very common disease, whether associated with defecation disorders or not. Lifestyle and dietary measures and even laxatives, which represent the cornerstone of its management, rely on weak evidence. In addition, patients are frequently dissatisfied with commonly prescribed laxatives. New pharmacologic treatments of constipation have recently emerged, with a novel enterokinetic activity. Prucalopride (Resolor®) will be the first treatment of this kind available in France. Others are expected, and this new class of agents probably announces a change of era in the management of slow-transit constipation, which therapeutic strategy should be permanently modified.

Keywords

Slow-transit constipation Laxatives Enterokinetic treatments 

Constipation de transit : les traitements ayant fait la preuve de leur efficacité

Résumé

La constipation de transit est une pathologie très fréquente, qu’elle soit isolée ou associée à une constipation terminale. Les règles hygiénodiététiques et même les traitements laxatifs qui constituent la pierre angulaire de la prise en charge reposent pourtant sur un niveau de preuve faible. De plus, le niveau d’insatisfaction vis-à-vis des laxatifs couramment prescrits demeure élevé chez ces patients. De nouveaux traitements pharmacologiques de la constipation ont récemment émergé, dotés d’une action entérokinétique inédite. Le prucalopride (Resolor®) sera le premier médicament de ce type disponible en France. D’autres sont attendus, et cette nouvelle gamme augure d’un probable changement d’ère dans la prise en charge de la constipation de transit, dont la stratégie thérapeutique devrait être durablement remaniée.

Mots clés

Constipation de transit Laxatifs Traitements entérokinétiques 

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Copyright information

© Springer Verlag France 2011

Authors and Affiliations

  1. 1.Service de proctologie médicochirurgicalegroupe hospitalier Diaconesses-Croix-Saint-Simon, site ReuillyParisFrance
  2. 2.Service de gastroentérologiehôpital Henri-MondorCréteilFrance
  3. 3.Service d’hépatogastroentérologiehôpital européen Georges-PompidouParisFrance

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