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Facile preparation of low swelling, high strength, self-healing and pH-responsive hydrogels based on the triple-network structure

  • Zhicun Wang
  • Xiaoman Han
  • Yixi Wang
  • Kenan Men
  • Lin CuiEmail author
  • Jianning Wu
  • Guihua Meng
  • Zhiyong LiuEmail author
  • Xuhong Guo
Research Article
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Abstract

A polyacrylic acid (PAA)/gelatin (Gela)/polyvinyl alcohol (PVA) hydrogel was prepared by copolymerization, cooling, and freezing/thawing methods. This triplenetwork (TN) structure hydrogel displayed superior mechanical properties, low swelling ratio and self-healing properties. The superior mechanical properties are attributed to the triple helix association of Gela and PVA crystallites by reversible hydrogen bonding. The characterization results indicated that the fracture stress and the strain were 808 kPa and 370% respectively, while the compression strength could reach 4443 kPa and the compressive modulus was up to 39 MPa under the deformation of 90%. The hydrogen bonding in PVA contributed to maintain and improve the self-healing ability of hydrogels. Every type of hydrogels exhibited a higher swelling ratio under alkaline conditions, and the swelling ratios of PAA, PAA/PVA and PAA/Gela hydrogels were 27.71, 12.30 and 9.09, respectively. The PAA/Gela/PVA TN hydrogel showed the lowest swelling ratio (6.57) among these hydrogels. These results indicate that the novel TN hydrogels possess good environmental adaptability and have potential applications in the biomedical engineering and sensor field.

Keywords

hydrogel triple-network structure mechanical property swelling selfhealing 

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Notes

Acknowledgements

This work was supported financially by funding from the National Natural Science Foundation of China (Grant Nos. 51662036 and 21467024) and the Graduate Student Scientific Research Innovation Projects in Xinjiang Autonomous Region, China (XJGRI2017046).

References

  1. [1]
    Liu X, Duan L, Gao G. Rapidly self-recoverable and fatigueresistant hydrogels toughened by chemical crosslinking and hydrophobic association. European Polymer Journal, 2017, 89: 185–194CrossRefGoogle Scholar
  2. [2]
    Tavsanli B, Can V, Okay O. Mechanically strong triple network hydrogels based on hyaluronan and poly(N,N-dimethylacrylamide). Soft Matter, 2015, 11(43): 8517–8524CrossRefGoogle Scholar
  3. [3]
    Frederix P W, Kania R, Wright J A, et al. Encapsulating [FeFe]-hydrogenase model compounds in peptide hydrogels dramatically modifies stability and photochemistry. Dalton Transactions, 2012, 41(42): 13112–13119CrossRefGoogle Scholar
  4. [4]
    Yin H, Akasaki T, Sun T L, et al. Double network hydrogels from polyzwitterions: high mechanical strength and excellent antibiofouling properties. Journal of Materials Chemistry B: Materials for Biology and Medicine, 2013, 1(30): 3685–3693CrossRefGoogle Scholar
  5. [5]
    Fan C, Liao L, Zhang C, et al. A tough double network hydrogel for cartilage tissue engineering. Journal of Materials Chemistry B: Materials for Biology and Medicine, 2013, 1(34): 4251–4258CrossRefGoogle Scholar
  6. [6]
    Xu R, Zhou G, Tang Y, et al. New double network hydrogel adsorbent: Highly efficient removal of Cd(II) and Mn(II) ions in aqueous solution. Chemical Engineering Journal, 2015, 275: 179–188CrossRefGoogle Scholar
  7. [7]
    Hu Y, Du Z, Deng X, et al. Dual physically cross-linked hydrogels with high stretchability, toughness, and good self-recoverability. Macromolecules, 2016, 49(15): 5660–5668CrossRefGoogle Scholar
  8. [8]
    Kamata H, Akagi Y, Kayasuga-Kariya Y, et al. “Nonswellable” hydrogel without mechanical hysteresis. Science, 2014, 343 (6173): 873–875CrossRefGoogle Scholar
  9. [9]
    Zhuang Y, Yu F, Chen H, et al. Alginate/graphene double-network nanocomposite hydrogel bead with low-swelling, enhanced mechanical property, and enhanced adsorption capacity. Journal of Materials Chemistry A: Materials for Energy and Sustainability, 2016, 4(28): 10885–10892CrossRefGoogle Scholar
  10. [10]
    Yu P, Bao R Y, Shi X J, et al. Self-assembled high-strength hydroxyapatite/graphene oxide/chitosan composite hydrogel for bone tissue engineering. Carbohydrate Polymers, 2017, 155: 507–515CrossRefGoogle Scholar
  11. [11]
    Shao C, Chang H, Wang M, et al. High-strength, tough, and selfhealing nanocomposite physical hydrogels based on the synergistic effects of dynamic hydrogen bond and dual coordination bonds. ACS Applied Materials & Interfaces, 2017, 9(34): 28305–28318CrossRefGoogle Scholar
  12. [12]
    Xin H, Saricilar S Z, Brown H R, et al. Effect of first network topology on the toughness of double network hydrogels. Macromolecules, 2013, 46(16): 6613–6620CrossRefGoogle Scholar
  13. [13]
    Li H, Hao D, Fan J, et al. A robust double-network hydrogel with under sea water superoleophobicity fabricated via one-pot, onestep reaction. Journal of Materials Chemistry B: Materials for Biology and Medicine, 2016, 4(27): 4662–4666CrossRefGoogle Scholar
  14. [14]
    Wang Y, Yan J, Wang Z, et al. One-pot fabrication of triplenetwork structure hydrogels with high-strength and self-healing properties. Materials Letters, 2017, 207: 53–56CrossRefGoogle Scholar
  15. [15]
    Jiang X, Xiang N, Wang J, et al. Preparation and characterization of hybrid double network chitosan/poly(acrylic amide-acrylic acid) high toughness hydrogel through Al3+ crosslinking. Carbohydrate Polymers, 2017, 173: 701–706CrossRefGoogle Scholar
  16. [16]
    Chen Q, Chen H, Zhu L, et al. Fundamentals of double network hydrogels. Journal of Materials Chemistry B: Materials for Biology and Medicine, 2015, 3(18): 3654–3676CrossRefGoogle Scholar
  17. [17]
    Singh N, Maity C, Zhang K, et al. Synthesis of a double network supramolecular hydrogel by having one network catalyse the formation of the second. Chemistry -A European Journal, 2017, 23(9): 2018–2021CrossRefGoogle Scholar
  18. [18]
    Gong J P, Katsuyama Y, Kurokawa T, et al. Double-network hydrogels with extremely high mechanical strength. Advanced Materials, 2003, 15(14): 1155–1158CrossRefGoogle Scholar
  19. [19]
    Chen H, Chen Q, Hu R, et al. Mechanically strong hybrid double network hydrogels with antifouling property. Journal of Materials Chemistry B: Materials for Biology and Medicine, 2015, 3(27): 5426–5435CrossRefGoogle Scholar
  20. [20]
    Zhu P, Hu M, Deng Y, et al. One-pot fabrication of a novel agarpolyacrylamide/graphene oxide nanocomposite double network hydrogel with high mechanical properties. Advanced Engineering Materials, 2016, 18(10): 1799–1807CrossRefGoogle Scholar
  21. [21]
    Nakayama A, Kakugo A, Gong J P, et al. High mechanical strength double-network hydrogel with bacterial cellulose. Advanced Functional Materials, 2004, 14(11): 1124–1128CrossRefGoogle Scholar
  22. [22]
    Weng L, Gouldstone A, Wu Y, et al. Mechanically strong double network photocrosslinked hydrogels from N, N-dimethylacrylamide and glycidyl methacrylated hyaluronan. Biomaterials, 2008, 29(14): 2153–2163CrossRefGoogle Scholar
  23. [23]
    Waters D J, Engberg K, Parke-Houben R, et al. Structure and mechanism of strength enhancement in interpenetrating polymer network hydrogels. Macromolecules, 2011, 44(14): 5776–5787CrossRefGoogle Scholar
  24. [24]
    Gulyuz U, Okay O. Self-healing polyacrylic acid hydrogels. Soft Matter, 2013, 9(43): 10287–10293CrossRefGoogle Scholar
  25. [25]
    Wang Y, Niu J, Hou J, et al. A novel design strategy for triplenetwork structure hydrogels with high-strength, tough and selfhealing properties. Polymer, 2018, 135: 16–24CrossRefGoogle Scholar
  26. [26]
    Jia H, Huang Z, Fei Z, et al. Unconventional tough doublenetwork hydrogels with rapid mechanical recovery, self-healing, and self-gluing properties. ACS Applied Materials & Interfaces, 2016, 8(45): 31339–31347CrossRefGoogle Scholar
  27. [27]
    Wang X, Deng W, Xie Y, et al. Selective removal of mercury ions using a chitosan–poly(vinyl alcohol) hydrogel adsorbent with three-dimensional network structure. Chemical Engineering Journal, 2013, 228: 232–242CrossRefGoogle Scholar
  28. [28]
    Wang Y, Wang Z, Wu K, et al. Synthesis of cellulose-based double-network hydrogels demonstrating high strength, selfhealing, and antibacterial properties. Carbohydrate Polymers, 2017, 168: 112–120CrossRefGoogle Scholar
  29. [29]
    Tang Q, Sun X, Li Q, et al. A simple route to interpenetrating network hydrogel with high mechanical strength. Journal of Colloid and Interface Science, 2009, 339(1): 45–52CrossRefGoogle Scholar
  30. [30]
    Sun W, Xue B, Li Y, et al. Polymer-supramolecular polymer double-network hydrogel. Advanced Functional Materials, 2016, 26(48): 9044–9052CrossRefGoogle Scholar
  31. [31]
    Wang Y, Zhang C, Zhao L, et al. Cellulose-based porous adsorbents with high capacity for methylene blue adsorption from aqueous solutions. Fibers and Polymers, 2017, 18(5): 891–899CrossRefGoogle Scholar
  32. [32]
    Sabzi M, Samadi N, Abbasi F, et al. Bioinspired fully physically cross-linked double network hydrogels with a robust, tough and self-healing structure. Materials Science and Engineering C, 2017, 74: 374–381CrossRefGoogle Scholar
  33. [33]
    Alavijeh R Z, Shokrollahi P, Barzin J. A thermally and water activated shape memory gelatin physical hydrogel, with a gel point above the physiological temperature, for biomedical applications. Journal of Materials Chemistry B: Materials for Biology and Medicine, 2017, 5(12): 2302–2314CrossRefGoogle Scholar
  34. [34]
    Gornall J L, Terentjev E M. Helix–coil transition of gelatin: helical morphology and stability. Soft Matter, 2008, 4(3): 544–549CrossRefGoogle Scholar
  35. [35]
    Cui L, Jia J, Guo Y, et al. Preparation and characterization of IPN hydrogels composed of chitosan and gelatin cross-linked by genipin. Carbohydrate Polymers, 2014, 99: 31–38CrossRefGoogle Scholar
  36. [36]
    Li X, Yang Q, Zhao Y, et al. Dual physically crosslinked double network hydrogels with high toughness and self-healing properties. Soft Matter, 2017, 13(5): 911–920CrossRefGoogle Scholar
  37. [37]
    Gong J P. Why are double network hydrogels so tough? Soft Matter, 2010, 6(12): 2583–2590CrossRefGoogle Scholar
  38. [38]
    Zhao X. Multi-scale multi-mechanism design of tough hydrogels: building dissipation into stretchy networks. Soft Matter, 2014, 10 (5): 672–687CrossRefGoogle Scholar
  39. [39]
    Miyazaki T, Hoshiko A, Akasaka M, et al. SAXS studies on structural changes in a poly(vinyl alcohol) film during uniaxial stretching in water. Macromolecules, 2006, 39(8): 2921–2929CrossRefGoogle Scholar
  40. [40]
    Li J, Suo Z, Vlassak J J. Stiff, strong, and tough hydrogels with good chemical stability. Journal of Materials Chemistry B: Materials for Biology and Medicine, 2014, 2(39): 6708–6713CrossRefGoogle Scholar
  41. [41]
    Na Y, Tanaka Y, Kawauchi Y, et al. Necking phenomenon of double-network gels. Macromolecules, 2006, 39(14): 4641–4645CrossRefGoogle Scholar

Copyright information

© Higher Education Press and Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  • Zhicun Wang
    • 1
  • Xiaoman Han
    • 1
  • Yixi Wang
    • 1
  • Kenan Men
    • 2
  • Lin Cui
    • 3
    Email author
  • Jianning Wu
    • 1
  • Guihua Meng
    • 1
  • Zhiyong Liu
    • 1
    Email author
  • Xuhong Guo
    • 1
    • 4
  1. 1.School of Chemistry and Chemical EngineeringShihezi University/Key Laboratory for Green Processing of Chemical Engineering of Xinjiang Bingtuan/Key Laboratory of Materials-Oriented Chemical Engineering of Xinjiang Uygur Autonomous Region/Engineering Research Center of Materials-Oriented Chemical Engineering of Xinjiang BingtuanShiheziChina
  2. 2.Bingtuan Sishi HospitalYiliChina
  3. 3.School of MedicineShihezi UniversityShiheziChina
  4. 4.State Key Laboratory of Chemical EngineeringEast China University of Science and TechnologyShanghaiChina

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