Frontiers of Chemical Science and Engineering

, Volume 8, Issue 3, pp 362–368

Development of a multi-component drug from turmeric using central composite design

  • Xiaohang Zhang
  • Shengnan Han
  • Yan Li
  • Jianlan Jiang
Research Article

DOI: 10.1007/s11705-014-1439-5

Cite this article as:
Zhang, X., Han, S., Li, Y. et al. Front. Chem. Sci. Eng. (2014) 8: 362. doi:10.1007/s11705-014-1439-5

Abstract

A methodology to develop multi-component drugs based on traditional Chinese medicines has been developed using central composite design. Several active components from the traditional Chinese medicine turmeric were chosen for use in a multi-component antitumor drug. Response surface methodology based on a central composite design was applied to determine the quantitative composition-activity relationships in order to optimize the amount of each component in the drug. An MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay was used to measure the pharmacological activity as the response value. The experimental antitumor activity of the optimum combination was 92.85% in the MTT assay and superior to the activities of each single component. These results demonstrate that response surface methodology based on a central composite design is suitable for the design of multi-component drugs.

Keywords

multi-component drug development central composite design turmeric curcuminoids 

Copyright information

© Higher Education Press and Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  • Xiaohang Zhang
    • 1
  • Shengnan Han
    • 1
  • Yan Li
    • 1
  • Jianlan Jiang
    • 1
  1. 1.Key Laboratory of Systems Bioengineering, Ministry of Education, School of Chemical Engineering and TechnologyTianjin UniversityTianjinChina

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