Abstract
To compare tissue trauma between Retropubic Radical Prostatectomy and Robotically Assisted Laparoscopic Radical Prostatectomy by inflammatory mediators. Serum samples from 40 patients submitted to RALP and 20 patients submitted to RRP were withdrawn at four different time points. The cytokines IL-4, IL-8, IL-6, IL-1B, IL-10 and TNF-α were detected using ELISA/Multiplex assays and xMAP—Luminex®. With both techniques, IL-10 and IL-6 were higher in T4 than in T1–T3 (p = 0.001). IL-10 and IL-6 were higher in T4 in open surgery than in robotic surgery (p = 0.000 and p = 0.001, respectively). Compared with both groups, IL-6 and IL-10 were higher in T4 in open surgery than in robotic surgery. Thus, we can postulate that RALP causes less tissue trauma than classical RRP, as indicated by the more limited increase in inflammatory mediators such as IL-6 and IL-10.
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The datasets used and/or analyzed during the current study are available from the corresponding author upon reasonable request.
Abbreviations
- APR:
-
Acute-phase Reaction
- IL:
-
Interleukins
- IL-10:
-
Interleukin 10
- IL-1β:
-
Interleukin 1β
- IL-4:
-
Interleukin 4
- IL-6:
-
Interleukin 6
- IL-8:
-
Interleukin 8
- LRP:
-
Laparoscopic prostatectomy
- PCa:
-
Prostate cancer
- RALP:
-
Robotically assisted laparoscopic radical prostatectomy
- RP:
-
Radical prostatectomy
- RRP:
-
Retropubic radical prostatectomy
- TNF-α:
-
Tumor necrosis factor alpha
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Denise Quinto, Sabrina T. Reis, Lucca Juvele Zampolli, Ruan Pimenta, Vanessa R Guimarães, Nayara I. Viana, Gabriel A. dos Santos, Mario P. Gimenez, Katia R. Leite, Hamilton Zampolli, José Arnaldo S. da Cruz, Miguel Srougi, Carlo C. Passerotti declare that they have no conflict of interest.
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All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration of 1975, as revised in 2000. Informed consent was obtained from all patients for being included in the study. This study was submitted and approved by the Research Ethics Committee of the University of Sao Paulo Medical School under number 1.604.785.
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Quinto, D., Reis, S.T., Zampolli, L.J. et al. Robotically assisted laparoscopic radical prostatectomy induces lower tissue trauma than radical retropubic prostatectomy. J Robotic Surg 15, 147–151 (2021). https://doi.org/10.1007/s11701-020-01150-y
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DOI: https://doi.org/10.1007/s11701-020-01150-y