APTES (3-aminopropyltriethoxy silane) functionalized MnFe2O4 nanoparticles: a potential material for magnetic fluid hyperthermia

  • P. R. Ghutepatil
  • A. B. Salunkhe
  • V. M. Khot
  • S. H. PawarEmail author
Original Paper


Magnetic nanoparticles have the potential to be used for biomedical applications, specifically in painless curing of cancer. The primary objective of this article is to prepare 3-aminopropyltriethoxy silane (APTES) functionalized magnetic nanoparticles by using polyol synthesis method in order to use them for magnetic hyperthermia application. The obtained magnetic nanoparticles were characterized by using X-ray diffraction, scanning electron microscope, transmission electron microscopy, vibrating sample magnetometry, fourier transform infrared spectroscopy and thermogravimetric analysis techniques for structural, morphological and magnetic analysis. Structural analysis showed that the mean crystallite size of prepared nanoparticles was about 13 nm and magnetic study exhibited that the bare and functionalized nanoparticles were superparamagnetic at room temperature. Induction heating study was performed by applying external AC magnetic field of 167.6–335.2 Oe at a fixed frequency of 265 kHz to assess the feasibility for magnetic hyperthermia anticancer therapy. Maximum specific absorption rate 261.53 W g−1 has observed at 335.2 Oe (265 kHz) for APTES coated nanoparticles. Cell viability study revealed that APTES functionalized MnFe2O4 nanoparticles can be potential heating agent for cancer hyperthermia therapy as nanoparticles have almost no toxicity.

Graphical abstract


MnFe2O4 nanoparticles Polyol synthesis APTES coating Hyperthermia 



The magnetic measurements were performed at UGC-DAE Consortium for Scientific Research, Indore. Authors are very much thankful to Dr. Alok Banergee, UGC-DAE, CSR Indore for VSM analysis.


No funding was received.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.


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Copyright information

© Institute of Chemistry, Slovak Academy of Sciences 2019

Authors and Affiliations

  • P. R. Ghutepatil
    • 1
  • A. B. Salunkhe
    • 2
  • V. M. Khot
    • 3
  • S. H. Pawar
    • 1
    • 4
    Email author
  1. 1.Center for Interdisciplinary ResearchD. Y. Patil UniversityKolhapurIndia
  2. 2.Department of PhysicsElphinston CollegeMumbaiIndia
  3. 3.Dr. D.Y. Patil Institute of Engineering, Management and ResearchPuneIndia
  4. 4.Center for Innovative and Applied Research Anekant Education SocietyT.C. CollegeBaramatiIndia

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