FeCl2·4H2O catalyzed ritter reaction with nitriles and halohydrocarbons
- 15 Downloads
An efficient and inexpensive synthesis of N-substituted amides from the Ritter reaction of nitriles with various halohydrocarbons catalyzed by FeCl2·4H2O is described. FeCl2·4H2O economically efficiently catalyzed the Ritter reaction under solvent-free conditions. A range of halohydrocarbons (benzyl, tert-butyl and sec-alkyl halohydrocarbons) were coupled with nitriles to provide the corresponding amides in high to excellent yields.
KeywordsFeCl2·4H2O Amides Nitriles Halohydrocarbons Ritter reaction
We are grateful to Nantong City Science Foundation (No. 2015) and Science program of Jiangsu College of Engineering and Technology for financial support.
- Zhao XN, Hu CH, Zhang FJ, Zhang ZH (2014) Magnetic CoFe2O4 nanoparticle immobilized N-propyl diethylenetriamine sulfamic acid as an efficient and recyclable catalyst for the synthesis of amides via the Ritter reaction. Appl Catal A 482:258–265. https://doi.org/10.1016/j.apcata.2014.06.006 CrossRefGoogle Scholar