Biocatalytic one-pot three-component synthesis of 4H-chromene derivatives in non-aqueous medium
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The baker’s yeast catalyzed one-pot three-component cyclocondensation of salicylaldehyde, malononitrile or ethyl cyanoacetate, and nitroalkanes for the synthesis of substituted 2-amino-4H-chromene derivatives is presented. The highlights of the protocol is a use of a biodegradable catalyst which is inexpensive, having simple reaction conditions, in other words, at room temperature and neutral pH, good-to-excellent yield, and simple workup procedure.
KeywordsBaker’s yeast Chromene Knoevenagel condensation Michael addition Biocatalysis
Authors are thankful to Science and Engineering Research Board (SB/EMEQ-279/2013), New Delhi, for providing the financial support. We are grateful to Professor Ramrao Mane for continuous guidance and valuable discussions. Authors are thankful to SAIF, Chandigarh University for providing spectral characterizations.
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