Chemical Papers

, Volume 71, Issue 11, pp 2075–2083 | Cite as

Study of the structure, prooxidative, and cytotoxic activity of some chelate copper(II) complexes

  • Vladimir P. Petrović
  • Marko N. Živanović
  • Dušica Simijonović
  • Jelena Đorović
  • Zorica D. Petrović
  • Snežana D. Marković
Original Paper
First Online:
Received:
Accepted:

Abstract

The six chelate N,O-copper(II) complexes were synthesised starting from salicylaldehyde anil Schiff bases, as ligands. Their structure is elucidated using experimental and theoretical tools. In vitro biological activities, i.e. cytotoxic and prooxidative effects against human epithelial mammary gland/breast metastatic carcinoma MDA-MB-231, epithelial colorectal carcinoma HCT-116, and foetal lung fibroblast healthy MRC-5 cell lines of investigated compounds are also determined. Complexes Cu-1, Cu-6, and especially Cu-7 showed significant cytotoxic effects, with IC50 values comparable with effects of positive control CisPt. In addition, investigated complexes induced extreme oxidative and nitrosative stress in all treated cell lines. The most prominent effect is observed on HCT-116 cells, and on MRC-5 cells, while MDA-MB-231 cells showed higher resistance to the investigated cell lines, giving us direction towards the substances with more specific selectivity.

Keywords

Chelate copper(II)–Schiff bases complexes Structure elucidation Cytotoxic activity Oxidative stress Prooxidative activity 
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Notes

Acknowledgements

This work was supported by the Ministry of Education, Science and Technological Development of the Republic of Serbia (Projects No. 172016, III41010).

Supplementary material

11696_2017_200_MOESM1_ESM.doc (4.6 mb)
Supplementary material 1 (DOC 4735 kb)

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Copyright information

© Institute of Chemistry, Slovak Academy of Sciences 2017

Authors and Affiliations

  • Vladimir P. Petrović
    • 1
  • Marko N. Živanović
    • 2
  • Dušica Simijonović
    • 1
  • Jelena Đorović
    • 1
    • 3
  • Zorica D. Petrović
    • 1
  • Snežana D. Marković
    • 2
  1. 1.Department of Chemistry, Faculty of ScienceUniversity of KragujevacKragujevacSerbia
  2. 2.Department of Biology and Ecology, Faculty of ScienceUniversity of KragujevacKragujevacSerbia
  3. 3.Bioengineering Research and Development CenterKragujevacSerbia

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