Long-term Impact of Mini-Gastric Bypass on Inflammatory Cytokines in Cohort of Morbidly Obese Patients: a Prospective Study

  • Mohamed Abdalla Salman
  • Ahmed Abdallah
  • Hani Maurice Sabri Mikhail
  • Ahmed Abdelsalam
  • Ayman Helmy Ibrahim
  • Ahmed Abd El Aal Sultan
  • Mohamed El-ghobary
  • Amro Abdelaziz Mohammed Ismail
  • Tarek Elsayed Abouelregal
  • Mahmoud Gouda Omar
  • Alhoussein Alsayed AbdelAal
  • Hossam El-Din Shaaban
  • Ghada M. K. GabAllah
  • Mohamed Tourky
  • Ahmed Abdallah SalmanEmail author
Original Contributions



One anastomosis gastric bypass (OAGB) is a promising bariatric procedure. We performed this study to evaluate the changes in a group of inflammatory cytokines 12 months after OAGB.


A single-arm prospective study was conducted on obese patients who underwent OAGB. The serum levels of the following adipocytokines were monitored pre- and 12 months postoperatively: adiponectin, leptin, interleukin 6 (IL-6), interleukin 8 (IL-8) levels, tumor necrosis factor-alpha (TNF-α), serum amyloid A (SAA), high-sensitivity C-reactive protein (hs-CRP), and monocyte chemotactic protein 1 (MCP-1).


A total of 62 patients were included with a mean age of 43.9 ± 6.8 years old. The serum adiponectin increased significantly from 7.64 ± 0.29 to 8.76 ± 0.42 μg/mL 12 months after the operation (p < 0.001). hs-CRP and IL-6 decreased significantly 12 months after the OAGB from 3323.35 ± 643.4 ng/mL and 3.72 ± 7.7 pg/mL to 1376.81 ± 609.4 ng/mL and 3.64 ± 6.9 pg/mL, respectively (p < 0.001). The MCP-1 showed significant increase in its level after OAGB as well (p = 0.014). In contrary, there were no significant changes in serum levels of IL-8 (p = 0.12) and TNF-α (p = 0.84) 12 months after the operation. The correlation analysis showed significant correlations between initial body mass index (BMI) with serum adiponectin, IL-8, and serum SAA.


OAGB can significantly impact the inflammatory cytokine profile in obese patients with possible subsequent protection from obesity-related comorbidities such as insulin resistance, cardiovascular diseases, and certain cancers.


Bariatric surgery Inflammatory Adipokines One anastomosis gastric bypass 


Compliance with Ethical Standards

Conflict of Interest

The authors declare that they have no conflict of interest.


Informed consent was obtained from all individual participants included in the study.


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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2020

Authors and Affiliations

  • Mohamed Abdalla Salman
    • 1
  • Ahmed Abdallah
    • 1
  • Hani Maurice Sabri Mikhail
    • 1
  • Ahmed Abdelsalam
    • 1
  • Ayman Helmy Ibrahim
    • 2
  • Ahmed Abd El Aal Sultan
    • 2
  • Mohamed El-ghobary
    • 3
  • Amro Abdelaziz Mohammed Ismail
    • 3
  • Tarek Elsayed Abouelregal
    • 3
  • Mahmoud Gouda Omar
    • 3
  • Alhoussein Alsayed AbdelAal
    • 4
  • Hossam El-Din Shaaban
    • 5
  • Ghada M. K. GabAllah
    • 6
  • Mohamed Tourky
    • 7
  • Ahmed Abdallah Salman
    • 3
    Email author
  1. 1.General Surgery Department, Faculty of MedicineCairo UniversityGizaEgypt
  2. 2.General Surgery Department, Faculty of MedicineAl-Azhar UniversityCairoEgypt
  3. 3.Internal Medicine Department, Faculty of MedicineCairo UniversityGizaEgypt
  4. 4.Internal Medicine Department, Faculty of MedicineZagazig UniversityZagazigEgypt
  5. 5.National Hepatology and Tropical Medicine Research InstituteCairoEgypt
  6. 6.Medical Biochemistry Department, Faculty of MedicineMenoufia UniversityShibin El KomEgypt
  7. 7.Alawi TunsiMeccaSaudi Arabia

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