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The Influence of Persistent Organic Pollutants on Thyroidal, Reproductive and Adrenal Hormones After Bariatric Surgery

  • Aina JansenEmail author
  • Jens Petter Berg
  • Ole Klungsøyr
  • Mette Helen Bjørge Müller
  • Jan Ludvig Lyche
  • Jan Olav Aaseth
Original Contributions
  • 54 Downloads

Abstract

Introduction

Persistent organic pollutants (POPs) including organochlorine pesticides, polychlorinated biphenyls (PCBs), and per- and polyfluoroalkylated substances (PFASs) are suspected endocrine disruptors.

Aim

To evaluate the associations between POPs and thyroidal, reproductive, and adrenal hormones in a study population treated with bariatric surgery.

Methods

Blood samples from a cohort of 63 participants before and 1 year after bariatric surgery were analyzed for 16 lipophilic POPs, 17 PFASs, and thyroidal, reproductive, and adrenal hormones. Participants reporting relevant medical conditions or interfering medication were excluded, and plausible confounders were corrected for in multiple regression analyses.

Results

Free thyroxine (fT4) showed a significant decrease from preoperative to postoperative follow-up, and regression analyses demonstrated that p,p'-dichlorodiphenyldichloroethylene (p,p-DDE) was inversely associated with the ratio free triiodothyronine/free thyroxine (fT3/fT4). Testosterone concentrations in male participants increased significantly in the study period, and sex hormone-binding globulin (SHBG) increased in both gender. Regression analyses showed positive associations between increased levels of lipophilic POPs and the raised postoperative testosterone and SHBG concentrations in males. For females, an inverse association between the sum perfluoroalkyl carboxylic acids (ΣPFCA) and SHBG was seen. Regression analyses of postoperative serum cortisol concentrations on changes in hexachlorobenzene (HCB) showed a non-significant inverse association.

Conclusion

The results suggest that POPs may have an influence on the hypothalamic-pituitary-thyroid (HPT) and the hypothalamic-pituitary-gonadal (HPG) axes after bariatric surgery. Because of small sample sizes and discrepancy in the sampling time points pre- and postoperatively, the observed hormonal impacts of POPs must be interpreted as associative and not causative. Further studies are needed to confirm the findings.

Keywords

Bariatric surgery Obesity Thyroid hormones Reproductive hormones Cortisol Endocrine disrupting chemicals 

Notes

Acknowledgments

We sincerely thank the study participants and surgical staff and colleagues at the surgical department, Innlandet Hospital Trust. The staff at all three laboratories are acknowledged for their contribution and service. Prof. Eystein Skjerve at NMBU is acknowledged for his scientific contribution.

Funding Information

This study was financially supported by the Innlandet Hospital Trust (grant number 150260).

Compliance with Ethical Standards

Conflict of Interest

The authors declare that they have no conflict of interest.

Ethical Approval

The study was approved by the Regional Committee for Medical and Health Research Ethics South East Norway, reference 2012/1394, and conducted in accordance with the Declaration of Helsinki.

Informed Consent

Written informed consent was obtained from all individual participants before inclusion in the study.

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Authors and Affiliations

  1. 1.Department of SurgeryInnlandet Hospital TrustGjøvikNorway
  2. 2.Department of Food Safety and Infection BiologyNorwegian University of Life Sciences (NMBU)OsloNorway
  3. 3.Department of Medical BiochemistryOslo University HospitalOsloNorway
  4. 4.Institute of Clinical MedicineOslo University HospitalOsloNorway
  5. 5.Centre for Biostatistics and Epidemiology, Section for Treatment Research, Department for Research and Education, Division of Mental Health and AddictionOslo University HospitalOsloNorway
  6. 6.Research DepartmentInnlandet Hospital TrustBrumunddalNorway
  7. 7.Faculty of Health and Social SciencesInland Norway University of Applied SciencesElverumNorway

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