No Effect on Change in Fasting Ghrelin at ≤ 12 Months and Increased at ≥ 24 Months After Roux-en-Y Gastric Bypass

  • Yong Wang
  • Jing Chen
  • Xiao-Ting WuEmail author
Letter to the Editor
We read with great interest about ghrelin level changes after undergoing Roux-en-Y gastric bypass (RYGB), which was a controversial outcome. Recently, a meta-analysis by Xu et al. [ 1] has demonstrated that fasting ghrelin decreased at ≤ 3 months and increased at > 3 months of follow-up after RYGB (standard mean difference (SMD) − 0.49; 95% confidence interval (CI) − 0.98, 0.00; SMD 0.46; 95% CI 0.22, 0.69, respectively). However, this meta-analysis suggested those results in the short term (≤ 3 months, including 32.3 ± 13.1 days, 6 weeks, and 3 months) and long term (> 3 months, range 6 months to 3.6 years). There was no subgroup analysis by detail follow-up time. We searched PubMed, EMBASE, and Web of Science for studies comparing fasting ghrelin pre- and post-RYGB in order to understand this dispute better. Not in line with the study of Xu et al. [ 1], twenty-six studies [ 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27] were included and...


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Conflict of Interest

The authors declare that they have no competing interests.


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© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Department of Gastrointestinal Surgery, West China HospitalSichuan UniversityChengduChina
  2. 2.Healthcare-Associated Infection Control CenterSichuan Academy of Medical Science and Sichuan Provincial People’s HospitalChengduChina

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