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No Effect on Change in Fasting Ghrelin at ≤ 12 Months and Increased at ≥ 24 Months After Roux-en-Y Gastric Bypass

  • Yong Wang
  • Jing Chen
  • Xiao-Ting WuEmail author
Letter to the Editor
  • 20 Downloads
We read with great interest about ghrelin level changes after undergoing Roux-en-Y gastric bypass (RYGB), which was a controversial outcome. Recently, a meta-analysis by Xu et al. [ 1] has demonstrated that fasting ghrelin decreased at ≤ 3 months and increased at > 3 months of follow-up after RYGB (standard mean difference (SMD) − 0.49; 95% confidence interval (CI) − 0.98, 0.00; SMD 0.46; 95% CI 0.22, 0.69, respectively). However, this meta-analysis suggested those results in the short term (≤ 3 months, including 32.3 ± 13.1 days, 6 weeks, and 3 months) and long term (> 3 months, range 6 months to 3.6 years). There was no subgroup analysis by detail follow-up time. We searched PubMed, EMBASE, and Web of Science for studies comparing fasting ghrelin pre- and post-RYGB in order to understand this dispute better. Not in line with the study of Xu et al. [ 1], twenty-six studies [ 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27] were included and...

Notes

Compliance with Ethical Standards

Conflict of Interest

The authors declare that they have no competing interests.

References

  1. 1.
    Xu HC, Pang YC, Chen JW, et al. Systematic review and meta-analysis of the change in ghrelin levels after roux-en-Y gastric bypass. Obes Surg. 2019;29(4):1343–51.CrossRefGoogle Scholar
  2. 2.
    Hansen EN, Tamboli RA, Isbell JM, et al. Role of the foregut in the early improvement in glucose tolerance and insulin sensitivity following roux-en-Y gastric bypass surgery. Am J Physiol Gastrointest Liver Physiol. 2011;300(5):G795–802.CrossRefGoogle Scholar
  3. 3.
    Oliván B, Teixeira J, Bose M, et al. Effect of weight loss by diet or gastric bypass surgery on peptide YY3-36 levels. Ann Surg. 2009;249(6):948–53.CrossRefGoogle Scholar
  4. 4.
    Peterli R, Steinert RE, Woelnerhanssen B, et al. Metabolic and hormonal changes after laparoscopic roux-en-Y gastric bypass and sleeve gastrectomy: a randomized. Prospective Trial Obes Surg. 2012;22(5):740–8.PubMedGoogle Scholar
  5. 5.
    Bose M, Machineni S, Oliván B, et al. Superior appetite hormone profile after equivalent weight loss by gastric bypass compared to gastric banding. Obesity (Silver Spring). 2010;18(6):1085–91.CrossRefGoogle Scholar
  6. 6.
    Bryant EJ, King NA, Falkén Y, et al. Relationships among tonic and episodic aspects of motivation to eat, gut peptides, and weight before and after bariatric surgery. Surg Obes Relat Dis. 2013;9(5):802–8.CrossRefGoogle Scholar
  7. 7.
    Carrasco F, Basfi-Fer K, Rojas P, et al. Changes in bone mineral density after sleeve gastrectomy or gastric bypass: relationships with variations in vitamin D, ghrelin, and adiponectin levels. Obes Surg. 2014;24(6):877–84.CrossRefGoogle Scholar
  8. 8.
    Chronaiou A, Tsoli M, Kehagias I, et al. Lower ghrelin levels and exaggerated postprandial peptide-YY, glucagon-like peptide-1,and insulin responses, after gastric fundus resection, in patients undergoing Roux-en-Y gastric bypass: a randomized clinical trial. Obes Surg. 2012;22(11):1761–70.CrossRefGoogle Scholar
  9. 9.
    Garcia-Fuentes E, Garrido-Sanchez L, Garcia-Almeida JM, et al. Different effect of laparoscopic roux-en-Y gastric bypass and open biliopancreatic diversion of Scopinaro on serum PYY and ghrelin levels. Obes Surg. 2008;18(11):1424–9.CrossRefGoogle Scholar
  10. 10.
    Kalinowski P, Paluszkiewicz R, Wróblewski T, et al. Ghrelin, leptin, and glycemic control after sleeve gastrectomy versus roux-en- Y gastric bypass-results of a randomized clinical trial. Surg Obes Relat Dis. 2017;13(2):181–8.CrossRefGoogle Scholar
  11. 11.
    Karamanakos SN, Vagenas K, Kalfarentzos F, et al. Weight loss, appetite suppression, and changes in fasting and postprandial ghrelin and peptide-YY levels after roux-en-Y gastric bypass and sleeve gastrectomy: a prospective, double blind study. Ann Surg. 2008;247(3):401–7.CrossRefGoogle Scholar
  12. 12.
    Mancini MC, Costa AP, de Melo ME, et al. Effect of gastric bypass on spontaneous growth hormone and ghrelin release profiles. Obesity (Silver Spring). 2006;14(3):383–7.CrossRefGoogle Scholar
  13. 13.
    Nosso G, Griffo E, Cotugno M, et al. Comparative effects of Rouxen-Y gastric bypass and sleeve gastrectomy on glucose homeostasis and incretin hormones in obese type 2 diabetic patients: a one-year prospective study. Horm Metab Res. 2016;48(5):312–7.CrossRefGoogle Scholar
  14. 14.
    O'Brien CS, Wang G, McGinty J, et al. Effects of gastrogastric fistula repair on weight loss and gut hormone levels. Obes Surg. 2013;23(8):1294–301.CrossRefGoogle Scholar
  15. 15.
    Pérez-Romero N, Serra A, Granada ML, et al. Effects of two variants of roux-en-Y gastric bypass on metabolism behaviour: focus on plasma ghrelin concentrations over a 2-year follow-up. Obes Surg. 2010;20(5):600–9.CrossRefGoogle Scholar
  16. 16.
    Terra X, Auguet T, Guiu-Jurado E, et al. Long-term changes in leptin, chemerin and ghrelin levels following different bariatric surgery procedures: roux-en-Y gastric bypass and sleeve gastrectomy. Obes Surg. 2013;23(11):1790–8.CrossRefGoogle Scholar
  17. 17.
    vander Zwaal EM, de Weijer BA, vande Giessen EM, et al. Striatal dopamine D2/3 receptor availability increases after long-term bariatric surgery-induced weight loss. Eur Neuropsychopharmacol. 2016;26(7):1190–200.CrossRefGoogle Scholar
  18. 18.
    Yousseif A, Emmanuel J, Karra E, et al. Differential effects of laparoscopic sleeve gastrectomy and laparoscopic gastric bypass on appetite, circulating acyl-ghrelin, peptide YY3-36 and active GLP-1 levels in non-diabetic humans. Obes Surg. 2014;24(2):241–52.CrossRefGoogle Scholar
  19. 19.
    Malin SK, Samat A, Wolski K, et al. Improved acylated ghrelin suppression at 2 years in obese patients with type 2 diabetes: effects of bariatric surgery vs standard medical therapy. Int J Obes. 2014;38(3):364–70.CrossRefGoogle Scholar
  20. 20.
    Ramón JM, Salvans S, Crous X, et al. Effect of roux-en-Y gastric bypass vs sleeve gastrectomy on glucose and gut hormones: a prospective randomised trial. J Gastrointest Surg. 2012;16(6):1116–22.CrossRefGoogle Scholar
  21. 21.
    Yang J, Gao Z, Williams DB, et al. Effect of laparoscopic roux-en-Y gastric bypass versus laparoscopic sleeve gastrectomy on fasting gastrointestinal and pancreatic peptide hormones: a prospective nonrandomized trial. Surg Obes Relat Dis. 2018;14(10):1521–9.CrossRefGoogle Scholar
  22. 22.
    Svane MS, BojsenMøller KN, Martinussen C, et al. Postprandial Nutrient Handling and Gastrointestinal Hormone Secretion After Roux-en-Y Gastric Bypass vs Sleeve Gastrectomy. Gastroenterology. 2019;156(6):1627–1641.e1.CrossRefGoogle Scholar
  23. 23.
    Nannipieri M, Baldi S, Mari A, et al. Roux-en-Y gastric bypass and sleeve gastrectomy: mechanisms of diabetes remission and role of gut hormones. J Clin Endocrinol Metab. 2013;98(11):4391–9.CrossRefGoogle Scholar
  24. 24.
    Alamuddin N, Vetter ML, Ahima RS, et al. Changes in fasting and prandial gut and adiposity hormones following vertical sleeve gastrectomy or roux-en-Y-gastric bypass: an 18-month prospective study. Obes Surg. 2017;27(6):1563–72.CrossRefGoogle Scholar
  25. 25.
    Borg CM. leRoux CW, Ghatei MA, bloom SR, Patel AG, Aylwin SJ, progressive rise in gut hormone levels after roux-en-Y gastric bypass suggests gut adaptation and explains altered satiety. Br J Surg. 2006;93(2):210–5.CrossRefGoogle Scholar
  26. 26.
    Tsouristakis AI, Febres G, McMahon DJ, Tchang B, Conwell IM, Tsang AJ, et al. Long-Term Modulation of Appetitive Hormones and Sweet Cravings After Adjustable Gastric Banding and Roux-en-Y Gastric Bypass. Obes Surg 2019Google Scholar
  27. 27.
    Stoeckli R, Chanda R, Langer I, et al. Changes of body weight and plasma ghrelin levels after gastric banding and gastric bypass. Obes Res. 2004;12(2):346–50.CrossRefGoogle Scholar

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© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Department of Gastrointestinal Surgery, West China HospitalSichuan UniversityChengduChina
  2. 2.Healthcare-Associated Infection Control CenterSichuan Academy of Medical Science and Sichuan Provincial People’s HospitalChengduChina

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