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Resting Energy Expenditure and Organ-Tissue Body Composition 5 Years After Bariatric Surgery

  • Stanley Heshka
  • Thaisa Lemos
  • Nerys M. Astbury
  • Elizabeth Widen
  • Lance Davidson
  • Bret H. Goodpaster
  • James P. DeLany
  • Gladys W. Strain
  • Alfons Pomp
  • Anita P. Courcoulas
  • Susan Lin
  • Isaiah Janumala
  • Wen Yu
  • Patrick Kang
  • John C. Thornton
  • Dympna GallagherEmail author
Original Contributions
  • 193 Downloads

Abstract

Introduction

Bariatric surgery–induced weight loss may reduce resting energy expenditure (REE) and fat-free mass (FFM) disproportionately thereby predisposing patients to weight regain and sarcopenia.

Methods

We compared REE and body composition of African-American and Caucasian Roux-en-Y gastric bypass (RYGB) patients after surgery with a group of non-operated controls (CON). REE by indirect calorimetry; skeletal muscle (SM), trunk organs, and brain volumes by MRI; and FFM by DXA were measured at post-surgery visits and compared with CON (N = 84) using linear regression models that adjusted for relevant covariates. Ns in RYGB were 50, 42, and 30 for anthropometry and 39, 27, 17 for MRI body composition at years 1, 2, and 5 after surgery, respectively.

Results

Regression models adjusted for age, weight, height, ethnicity, and sex showed REE differences (RYGB minus CON; mean ± s.e.): year 1 (43.2 ± 34 kcal/day, p = 0.20); year 2 (− 27.9 ± 37.3 kcal/day, p = 0.46); year 5 (114.6 ± 42.3 kcal/day, p = 0.008). Analysis of FFM components showed that RYGB had greater trunk organ mass (~ 0.4 kg) and less SM (~ 1.34 kg) than CON at each visit. REE models adjusted for FFM, SM, trunk organs, and brain mass showed no between-group differences in REE (− 15.9 ± 54.8 kcal/day, p = 0.8; − 46.9 ± 64.9 kcal/day, p = 0.47; 47.7 ± 83.0 kcal/day, p = 0.57, at years 1, 2, and 5, respectively).

Conclusions

Post bariatric surgery patients maintain a larger mass of high–metabolic rate trunk organs than non-operated controls of similar anthropometrics. Interpreting REE changes after weight loss requires an accurate understanding of fat-free mass composition at both the organ and tissue levels.

Clinical Trial Registration

Long-term Effects of Bariatric Surgery (LABS-2) NCT00465829

Keywords

Bariatric surgery Roux-en-Y gastric bypass Resting energy expenditure Body composition Fat-free mass Skeletal muscle Organs Brain 

Notes

Funding Information

This study was supported by the National Institutes of Health grants RO1-DK-72507, P30-DK-26687, and T32-DK007559 (supported TL, EW, and LD).

Compliance with Ethical Standards

Procedures performed in studies involving human participants were approved by the Institutional Review Boards of the relevant institutions and were in accordance with the ethical standards of the institutions and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Conflict of Interest

Nerys M. Astbury declares having been supported by a research grant from the Cambridge Weight Plan UK Ltd to the University of Oxford. Also, the terms of Nerys M. Astbury’s support require that the following statement be included in the paper: “Nerys M. Astbury is supported by funding from the National Institute for Health Research (NIHR), Oxford Biomedical Research Centre (BRC). The views expressed are those of the author(s) and not necessarily those of the NHS, the NIHR or the Department of Health and Social Care.”

The remaining authors declare that they have no conflict of interest.

Consent Statement

Written informed consent was obtained from all individual participants included in the study.

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • Stanley Heshka
    • 1
    • 2
  • Thaisa Lemos
    • 1
  • Nerys M. Astbury
    • 1
    • 3
  • Elizabeth Widen
    • 4
  • Lance Davidson
    • 5
  • Bret H. Goodpaster
    • 6
  • James P. DeLany
    • 6
  • Gladys W. Strain
    • 7
  • Alfons Pomp
    • 7
  • Anita P. Courcoulas
    • 8
  • Susan Lin
    • 9
  • Isaiah Janumala
    • 1
  • Wen Yu
    • 1
  • Patrick Kang
    • 10
  • John C. Thornton
    • 11
  • Dympna Gallagher
    • 1
    • 2
    • 12
    Email author
  1. 1.Department of Medicine, College of Physicians and SurgeonsColumbia University Medical CenterNew YorkUSA
  2. 2.Institute of Human NutritionColumbia UniversityNew YorkUSA
  3. 3.Nuffield Department of Primary Care Health Sciences and National Institutes of Health Research Biomedical Research CentreUniversity of OxfordOxfordUK
  4. 4.Department of Nutritional SciencesUniversity of Texas at AustinAustinUSA
  5. 5.Department of Exercise SciencesBrigham Young UniversityProvoUSA
  6. 6.Translational Research Institute for Metabolism and DiabetesOrlandoUSA
  7. 7.GI Metabolic and Bariatric SurgeryWeill Cornell MedicineNew YorkUSA
  8. 8.General Surgery, Department of MedicineUniversity of PittsburghPittsburghUSA
  9. 9.Center for Family and Community Medicine, Columbia University Medical CenterNew YorkUSA
  10. 10.New York Radiology PartnersNew YorkUSA
  11. 11.Thornton ConsultingMahopacUSA
  12. 12.Body Composition UnitColumbia University Medical CenterNew YorkUSA

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