Obesity Surgery

, Volume 30, Issue 2, pp 478–482 | Cite as

The Relationship Between Histopathologic Findings and Weight Loss in Laparoscopic Sleeve Gastrectomy

  • Taskin Erkinuresin
  • Hakan DemirciEmail author
  • Haci Murat Cayci
  • Umut Eren Erdogdu
Original Contributions



The aim of this study was to investigate the correlation between histopathologic findings detected in laparoscopic sleeve gastrectomy (LSG) specimens and excess weight loss percentages (%EWL) and excess BMI decrease percentages (%EBL).


Patients who underwent LSG in the hospital’s Gastroenterological Surgery Department between the years 2013 and 2018 and who completed 1 year of follow-up were involved in the study. Patients whose 6th month and 12th month BMI were unknown were excluded from the study. Clinical and pathologic data of the cases were obtained from the automation system of the hospital.


As a result of comparison among diagnosis groups, it was detected in the histopathologic analysis that the 12th month mean %EWL measurement was higher in the inactive stomach diagnosis group. In the comparisons among intestinal metaplasia (IM) groups, it was seen that 6th month %EWL and %EBL and 12th month %EWL and %EBL measurements were higher in the group without IM. Age, baseline BMI and active gastritis incidence in histopathologic analysis have a negative effect on weight loss.


A correlation of histopathologic changes in morbid obese patients with weight loss after bariatric surgery was asserted in this study. Operating on younger patients with lower BMI and inactive gastritis with the LSG method could contribute to achieving more successful results. Prospective research studies are necessary within this context.


Laparoscopic sleeve gastrectomy Excess Weight Loss Excess BMI Loss Intestinal metaplasia Gastritis 


Compliance with Ethical Standards

Conflict of Interest

The authors declare that they have no conflict of interest.


  1. 1.
    Adalı Y, Binnetoğlu K, Eroğlu HA, et al. The relationship between histopathologic findings and body mass index in sleeve gastrectomy materials. Obes Surg. 2019;29(1):277–80.CrossRefGoogle Scholar
  2. 2.
    Guh DP, Zhang W, Bansback N, et al. The incidence of comorbidities related to obesity and overweight: a systematic review and meta-analysis. BMC Public Health. 2009;25(9):88.CrossRefGoogle Scholar
  3. 3.
    Fryar CD, Carrol MD, Ogden CL. Prevalence of overweight, obesity, and extreme obesity among adults: United States, trends 1960–1962through 2009–2010, 2012. National Center of Health. Statistics, 2014.Google Scholar
  4. 4.
    Dogan U, Suren D, Oruc MT, et al. Spectrum of gastrichistopathologies in morbidly obese Turkish patients undergoing laparoscopic sleeve gastrectomy. Eur Rev Med Pharmacol Sci. 2017;21(23):5430–6.PubMedGoogle Scholar
  5. 5.
    Barak N, Ehrenpreis ED, Harrison JR, et al. Gastro-oesophageal reflux disease in obesity: pathophysiological and therapeutic considerations. Obes Rev. 2002;3:9–15.CrossRefGoogle Scholar
  6. 6.
    Fujimoto A, Hoteya S, Lizuka T, et al. Obesity and gastrointestinal diseases. Gastroenterol Res Pract. 2013;760574:2013.Google Scholar
  7. 7.
    Safaan T, Bashah M, El Ansari W, et al. Histopathological changes in laparoscopic sleeve gastrectomy specimens: prevalence, risk factors, and value of routine histopathologic examination. Obesitysurgery. 2017;27(7):1741–9.Google Scholar
  8. 8.
    Cayci HM, Erdogdu UE, Demirci H, et al. Effect of health literacy on help-seeking behavior in morbidly obese patients agreeing to bariatric surgery. Obes Surg. 2018;28(3):791–7.CrossRefGoogle Scholar
  9. 9.
    Onzi TR, d’Acampora AJ, de Araújo FM, et al. Gastric histopathology in laparoscopic sleeve gastrectomy: pre-and post-operative comparison. Obes Surg. 2014;24(3):371–6.CrossRefGoogle Scholar
  10. 10.
    Brethauer SA, Hammel JP, Schauer PR. Systematic review of sleeve gastrectomy as staging and primary bariatric procedure. Surg Obes Relat Dis. 2009;5(4):469–75.CrossRefGoogle Scholar
  11. 11.
    Ovaska JT, Havia TV, Pekkala ES, et al. Second follow-up study of mucosal changes in the gastric remnant after resection for peptic ulcer disease. Acta Chir Scand. 1989;155(1):35–8.PubMedGoogle Scholar
  12. 12.
    Abdul-Jabbar Hassawi B, Khalil KH, Sharafadin ZA. Prevalence of intestinal metaplasia and dysplasia in infectious and non-infectious chronic gastritis. Int J Res Med Sci. 2015;3(9):2228–31.CrossRefGoogle Scholar
  13. 13.
    Kim SH, Kim JW, Byun J, et al. Plasma ghrelin level and plasma ghrelin/obestatin ratio are related to intestinal metaplasia in elderly patients with functional dyspepsia. PLoS One. 2017;12(4):e0175231.CrossRefGoogle Scholar
  14. 14.
    Sabry Ahmed Mahmoud AF, Hussein W, Omar E, et al. Gastric mucosal changes and ghrelin expression and their relation to weight reduction after sleeve gastrectomy. J Dermatol Surg. 2018;6(2):36–42.Google Scholar
  15. 15.
    Vardar E, Öztürk AM, Ersoz D, et al. Routine careful histopathological examination should be performed in sleeve gastrectomy specimens. J Health Sci. 2017;7(1):44–9.CrossRefGoogle Scholar
  16. 16.
    Gündoğan M, Demirkan NÇ, Tekin K, et al. Gastric histopathological findings and ghrelin expression in morbid obesity. Turk Pathol J. 2013;29(1):19–26.CrossRefGoogle Scholar
  17. 17.
    Canil AM, Iossa A, PietroTermine DC, et al. Histopathology findings in patients undergoing laparoscopic sleeve gastrectomy. Obes Surg. 28:4) · January 2018.Google Scholar
  18. 18.
    Walędziak M, Różańska-Walędziak A, Janik MR, et al. Macroscopic evaluation of gastric specimens after laparoscopic sleeve gastrectomy—an optimum screening test for incidental pathologies? Obes Surg. 2019;
  19. 19.
    Miyazaki Y, Takiguchi S, Seki Y, et al. Clinical significance of ghrelin expression in the gastric mucosa of morbidly obese patients. World J Surg. 2013;37(12):2883–90.CrossRefGoogle Scholar
  20. 20.
    Ge L, Moon RC, Nguyen H, et al. Pathologic findings of the removed stomach during sleeve gastrectomy. Surg Endosc. 2019:1–5.Google Scholar

Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Pathology, University of Health Sciences Bursa Yuksek Ihtisas Training and Research HospitalBursaTurkey
  2. 2.Family MedicineUniversity of Health Sciences Bursa Yuksek Ihtisas Training and Research HospitalBursaTurkey
  3. 3.Gastrointestinal SurgeryUnivesity of Health Sciences Bursa Yuksek Ihtisas Training and Research HospitalBursaTurkey
  4. 4.Surgery, University of Health Sciences Bursa Yuksek Ihtisas Training and Research HospitalBursaTurkey

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