Advertisement

The Effect of the Intra-gastric Balloon on Gastric Emptying and the DeMeester Score

  • 84 Accesses

Abstract

Background and Aims

The mechanism of weight loss with the intra-gastric balloon (IGB) is thought to be a decrease in gastric emptying (GE); however the evidence is conflicting. Nausea, abdominal pain, and gastroesophageal reflux disease (GERD) can cause intolerance resulting in early removal. This is demoralizing for the patient and costly for the healthcare system. The ability to predict which patients will have superior weight loss and tolerance is invaluable. We sought to investigate if the IGB induced weight loss by reducing GE and the effect of the IGB on the DeMeester score.

Methods

We retrospectively reviewed prospectively collected data for patients undergoing IGB placement at a single hospital. Manometry and pH studies were performed before and with the IGB in place. Weight was measured at baseline, at removal, and 6 months later. Adverse events leading to early removal were recorded.

Results

Twenty-four patients were evaluated. There was a statistically significant decrease in GE for solids with the IGB (117.92 ± 150.23 vs 281.48 ± 206.49 min; p = 0.0048), but not for liquids (54.44 ± 17.97 vs 56.08 ± 43.96 min; p = 0.7228). The lower esophageal sphincter (LES) pressure did not change significantly with placement of the IGB (17.76 ± 7.39 vs 14.74 ± 7.24 mmHg; p = 0.09). On multivariate analysis, increase in DeMeester score was associated with total body weight loss (p = 0.0125) and change in GE (p = 0.038) independently.

Conclusion

The IGB delays GE for solids, but not for liquids, and increases the DeMeester score by a mechanism other than a loss of LES pressure.

This is a preview of subscription content, log in to check access.

Access options

Buy single article

Instant unlimited access to the full article PDF.

US$ 39.95

Price includes VAT for USA

Subscribe to journal

Immediate online access to all issues from 2019. Subscription will auto renew annually.

US$ 99

This is the net price. Taxes to be calculated in checkout.

Fig. 1
Fig. 2
Fig. 3

Abbreviations

IGB:

Intra-gastric balloon

GE:

Gastric emptying

GERD:

Gastroesophageal reflux disease

References

  1. 1.

    GBD 2015 Obesity Collaborators, Afshin A, Forouzanfar MH, et al. Health effects of overweight and obesity in 195 countries over 25 years. N Engl J Med. 2017;377(1):13–27.

  2. 2.

    Flegal KM, Carroll MD, Kit BK, et al. Prevalence of obesity and trends in the distribution of body mass index among US adults, 1999-2010. JAMA. 2012;307(5):491–7.

  3. 3.

    Gómez V, Woodman G, Abu Dayyeh BK. Delayed gastric emptying as a proposed mechanism of action during intragastric balloon therapy: results of a prospective study. Obesity (Silver Spring). 2016;24(9):1849–53.

  4. 4.

    Mion F, Napoléon B, Roman S, et al. Effects of intragastric balloon on gastric emptying and plasma ghrelin levels in non-morbid obese patients. Obes Surg. 2005;15(4):510–6.

  5. 5.

    Mathus-Vliegen LM, Tytgat GN. Twenty-four-hour pH measurements in morbid obesity: effects of massive overweight, weight loss and gastric distension. Eur J Gastroenterol Hepatol. 1996;8(7):635–40.

  6. 6.

    Trang J, Lee SS, Miller A, et al. Incidence of nausea and vomiting after intragastric balloon placement in bariatric patients - a systematic review and meta-analysis. Int J Surg. 2018;57:22–9.

  7. 7.

    Mathus-Vliegen EMH, Tytgat GNJ. Intragastric balloon for treatment-resistant obesity: safety, tolerance, and efficacy of 1-year balloon treatment followed by a 1-year balloon-free follow-up. Gastrointest Endosc. 2005;61(1):19–27.

  8. 8.

    Roman S, Napoléon B, Mion F, et al. Intragastric balloon for “non-morbid” obesity: a retrospective evaluation of tolerance and efficacy. Obes Surg. 2004;14(4):539–44.

  9. 9.

    Chang P, Friedenberg F. Obesity and GERD. Gastroenterol Clin N Am. 2014;43(1):161–73.

  10. 10.

    Friedenberg FK, Xanthopoulos M, Foster GD, et al. The association between gastroesophageal reflux disease and obesity. Am J Gastroenterol. 2008;103(8):2111–22.

  11. 11.

    Mathus-Vliegen EMH, Tygat GNJ. Gastro-oesophageal reflux in obese subjects: influence of overweight, weight loss and chronic gastric balloon distension. Scand J Gastroenterol. 2002;37(11):1246–52.

  12. 12.

    Rossi A, Bersani G, Ricci G, et al. Intragastric balloon insertion increases the frequency of erosive esophagitis in obese patients. Obes Surg. 2007;17(10):1346–9.

  13. 13.

    Hirsch DP, Mathus-Vliegen EMH, Dagli U, et al. Effect of prolonged gastric distention on lower esophageal sphincter function and gastroesophageal reflux. Am J Gastroenterol. 2003;98(8):1696–704.

  14. 14.

    Świdnicka-Siergiejko AK, Wróblewski E, Hady HR, et al. Esophageal pH and impedance reflux parameters in relation to body mass index, obesity-related hormones, and bariatric procedures. Polish Archives of Internal Medicine. 2018;128(10):594–603.

  15. 15.

    Mathus-Vliegen EMH, Eichenberger RI. Fasting and meal-suppressed ghrelin levels before and after intragastric balloons and balloon-induced weight loss. Obes Surg. 2014;24(1):85–94.

  16. 16.

    Papavramidis TS, Grosomanidis V, Papakostas P, et al. Intragastric balloon fundal or antral position affects weight loss and tolerability. Obes Surg. 2012;22(6):904–9.

  17. 17.

    Quiroga E, Cuenca-Abente F, Flum D, et al. Impaired esophageal function in morbidly obese patients with gastroesophageal reflux disease: evaluation with multichannel intraluminal impedance. Surg Endosc. 2006;20(5):739–43.

  18. 18.

    Crookes PF. Physiology of reflux disease: role of the lower esophageal sphincter. Surg Endosc. 2006;20(Suppl 2):S462–6.

  19. 19.

    Wu JC-Y, Mui L-M, Cheung CM-Y, et al. Obesity is associated with increased transient lower esophageal sphincter relaxation. Gastroenterology. 2007;132(3):883–9.

  20. 20.

    Wilson LJ, Ma W, Hirschowitz BI. Association of obesity with hiatal hernia and esophagitis. Am J Gastroenterol. 1999;94(10):2840–4.

  21. 21.

    Iovino P, Angrisani L, Galloro G, et al. Proximal stomach function in obesity with normal or abnormal oesophageal acid exposure. Neurogastroenterol Motil. 2006;18(6):425–32.

  22. 22.

    El-Serag HB, Tran T, Richardson P, et al. Anthropometric correlates of intragastric pressure. Scand J Gastroenterol. 2006;41(8):887–91.

Download references

Author information

Sergio Barrichello: Provided the patient cohort; analysis and interpretation of data; critical revision.

Dilhana Badurdeen: Analysis and interpretation of data; critical revision

Abdellah Hedjoudje: Analysis and interpretation of data; critical revision

Manoel Galvão Neto: Analysis and interpretation of data; critical revision

Robin Yance: Analysis and interpretation of data; critical revision

Andre Veinert: Analysis and interpretation of data; critical revision

Lea Fayad, MD: Analysis and interpretation of data; critical revision

Cem Simsek, MD: Analysis and interpretation of data; critical revision

Eduardo Grecco: Analysis and interpretation of data; critical revision

Thiago Ferreira de Souza: Analysis and interpretation of data; critical revision

Cynthia Teixeira: Analysis and interpretation of data; critical revision

Gabriel Cairo Nunes: Analysis and interpretation of data; critical revision

Anthony N. Kalloo: Analysis and interpretation of data; critical revision

Mouen A. Khashab: Analysis and interpretation of data; critical revision

Vivek Kumbhari: Drafting of article analysis and interpretation of data; critical revision; final approval

Correspondence to Vivek Kumbhari.

Ethics declarations

Ethical Approval

The ethics committee at the Hospital Estadual Mario Covas approved the IRB for the study.

Informed Consent

Informed consent does not apply.

Conflict of Interest

Anthony Kalloo is a founding Member, equity Holder and consultant for Apollo Endosurgery. Mouen A. Khashab is on the medical advisory board for Boston Scientific and Olympus America and is a consultant for Boston Scientific, Olympus America, and Medtronic. Vivek Kumbhari is a consultant for Medtronic, Reshape Lifesciences, Boston Scientific, Pentax Medical, and Apollo Endosurgery. He also receives research support from ERBE USA and Apollo Endosurgery. Manoel Galvão Neto is a consultant for Apollo Endosurgery and Ethicon endosurgery. Eduardo Grecco is a consultant for Apollo Endosurgery and Fractyl labs. Thiago Ferreira de Souza is a consultant for Apollo Endosurgery. All other authors declare that they have no conflict of interest.

Additional information

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Sergio Barrichello and Dilhana Badurdeen are co first authors for this paper.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Barrichello, S., Badurdeen, D., Hedjoudje, A. et al. The Effect of the Intra-gastric Balloon on Gastric Emptying and the DeMeester Score. OBES SURG 30, 38–45 (2020) doi:10.1007/s11695-019-04039-4

Download citation

Keywords

  • Intra-gastric balloon
  • Endoscopic bariatric therapy
  • DeMeester score
  • Gastric emptying