Effect of Bariatric Surgery on Serum Inflammatory Factors of Obese Patients: a Systematic Review and Meta-Analysis

  • Moein Askarpour
  • Dana Khani
  • Ali Sheikhi
  • Ehsan Ghaedi
  • Shahab AlizadehEmail author
Review Article


Obesity is one of the main causes of inflammation. Previous studies have reported inconclusive results regarding the effect of bariatric surgery on inflammatory markers. This systematic review and meta-analysis is aimed at describing the effect of bariatric surgery on C-reactive protein (CRP), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α). PubMed/Medline and Scopus were systematically searched for all eligible studies from inception to June 2018. Results are expressed as weighted mean difference (MD) with 95% confidence intervals (CI) using a random effects model. Overall, 116 studies which evaluated serum CRP, IL-6, and TNF-α after bariatric surgery were included. Pooled effect size showed significant reduction in serum CRP (− 5.30 mg/l, 95% CI − 5.46, − 5.15, P < 0.001), IL-6 (− 0.58 pg/ml, 95% CI − 0.64, − 0.53, P < 0.001), and TNF-α (− 0.20 pg/ml, 95% CI − 0.39, − 0.02, P = 0.031) with significant heterogeneity across studies (> 95% for all factors). Bariatric surgery significantly lowered inflammatory factors; however, baseline BMI, follow-up duration and type of surgery could impact the extent of observed effects.


Bariatric surgery C-reactive protein Interleukin 6 Tumor necrosis factor-α Meta-analysis 


Compliance with Ethical Standards

Ethical issues (including plagiarism, misconduct, data fabrication, falsification, double publication or submission, redundancy) have been completely observed by the authors.

Conflict of Interest

All authors declare that they have no conflict of interest.

Supplementary material

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Supplemental Fig. 3

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Supplemental Fig. 6 (DOCX 151 kb)


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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • Moein Askarpour
    • 1
  • Dana Khani
    • 2
  • Ali Sheikhi
    • 1
  • Ehsan Ghaedi
    • 1
    • 3
  • Shahab Alizadeh
    • 4
    Email author
  1. 1.Department of Community Nutrition, School of Nutritional Sciences and DieteticsTehran University of Medical SciencesTehranIran
  2. 2.Food Security Research Center and Department of Community Nutrition, School of Nutrition and Food SciencesIsfahan University of Medical SciencesIsfahanIran
  3. 3.Students’ Scientific Research Center (SSRC)Tehran University of Medical Sciences (TUMS)TehranIran
  4. 4.Department of Clinical Nutrition, School of Nutritional Sciences and DieteticsTehran University of Medical SciencesTehranIran

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